4-[2-[(2S,3R,4R)-5-[(1R)-1,2-二羟基乙基]-3,4-二羟基四氢呋喃-2-基]氧基-6-庚基-4-羟基苯甲酰基]氧基-2-庚基-6-羟基苯甲酸合成路线 （共 11 条）
反应条件
1: K2CO3, 18-crown-6 / acetone / 8 h / Heating
2: 90 percent / NaH, tetrabutylammonium iodide / tetrahydrofuran / 6 h / Ambient temperature
3: 96 percent / TBAF / tetrahydrofuran / 4 h / Ambient temperature
4: 4-DMAP, EDCI / CH2Cl2 / 4 h / Ambient temperature
5: TsOH / methanol / 0.5 h / Ambient temperature
6: 100 percent / H2 / 10percent Pd/C / ethanol / 14 h / 760 Torr
View Scheme
参考文献
Dushin; Danishefsky
Journal of the American Chemical Society, 1992 , vol. 114, # 2 p. 655 - 659
