2-氨基-6-氯-9-(beta-d-2-脱氧核糖)嘌呤合成路线 （共 6 条）
反应条件
1-(2-deoxy-β-D-erythropentofuranosyl)thymine; nucleoside deoxyribosyl transferase II T=40 - 50°C; 16 h; Enzymatic reaction; Product distribution / selectivity;
参考文献
Noguchi, Toshitada; Hamamoto, Tomoki; Okuyama, Kiyoshi; Shibuya, Susumu
Patent: US2005/170470 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
ammonia in methanol; dichloromethane
参考文献
ISIS Pharmaceuticals, Inc.
Patent: US5681941 A1, 1997 ;
反应条件
ammonia in methanol 20 h; Ambient temperature;
参考文献
Hanna; Ramasamy; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1899 - 1903
反应条件
nucleoside deoxyribosyltransferase-II; anhydrous trisodium citrate T=40°C; pH=6.4; 42 h; Enzymatic reaction;
参考文献
Okuyama, Kiyoshi; Shibuya, Susumu; Hamamoto, Tomoki; Noguchi, Toshitada
Bioscience, biotechnology, and biochemistry, 2003 , vol. 67, # 5 p. 989 - 995
反应条件
1: 51 percent / 1) sodium hydride (60percent in oil) / 1) acetonitrile, RT, 30 min; 2) acetonitrile, 20 h 2: 68 percent / NH3 / methanol / 20 h / Ambient temperature View Scheme
参考文献
Hanna; Ramasamy; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1899 - 1903
反应条件
sodium hydroxide; tris(hydroxymethyl)methylamine hydrochloride; adenosine deaminas in water T=40°C; pH=7; 13 h; Enzymatic reaction; Product distribution / selectivity;
参考文献
Noguchi, Toshitada; Hamamoto, Tomoki; Okuyama, Kiyoshi; Shibuya, Susumu
Patent: US2005/170470 A1, 2005 ;
Location in patent: Page/Page column 7 ;
