5-溴甲基-a,a,a',a'-四甲基-1,3-二乙氰基苯合成路线 （共 7 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 2 - 2.5 h; Heating / reflux;
参考文献
Glenmark Pharmaceuticals Limited
Patent: US2006/189670 A1, 2006 ;
Location in patent: Page/Page column 5; 7 ;
反应条件
potassium tert-butylate in toluene T=9 - 21°C; 4.5 h;
参考文献
EP2343278 A1, ;
Paragraph 0070 ;
反应条件
1: in N,N-dimethyl-formamide T=45 - 50°C; 4 h; 2: With hydrogenchloride; water T=50°C; pH=2; 3: With ammonia in water T=0 - 5°C; pH=8 - 9;
参考文献
US2008/207915 A1, ;
Page/Page column 5-6 ;
反应条件
1: 1H-1,2,4-triazol With sodium hydroxide in 1-methyl-pyrrolidin-2-one T=20 - 60°C; 14 - 55 h; 2: α,α,α',α'-tetramethyl-5-bromomethyl-1,3-benzene-diacetonitrile in 1-methyl-pyrrolidin-2-one T=-26 - -20°C; 18 - 26 h; 3: With acetic acid in 1-methyl-pyrrolidin-2-one pH=6.5 - 7; Product distribution / selectivity;
参考文献
WO2006/108155 A2, ;
Page/Page column 15-19 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide 2 h; Reflux; Product distribution / selectivity;
参考文献
WO2011/83079 A1, ;
Page/Page column 23-24 ;
反应条件
in N,N-dimethyl-formamide T=-10 - -5°C; 0.75 h; Product distribution / selectivity;
参考文献
WO2009/10991 A2, ;
Page/Page column 9; 10; 11; 11-12; 12; 13 ;
反应条件
in N,N-dimethyl-formamide T=-10 - -5°C; 0.75 h; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2009/10991 A2, 2009 ;
Location in patent: Page/Page column 9; 10; 11; 11-12; 12; 13 ;
