1-甲基-6-吲哚甲酸甲酯合成路线 （共 8 条）
反应条件
1: 1H-indole-6-carboxylic acid methyl ester With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 20 h;
参考文献
NEUROSEARCH A/S; PETERS, Dan; TIMMERMANN, Daniel, B.; DYHRING, Tino; CHRISTENSEN, Jeppe, Kejser; NIELSEN, Elsebet, OEstergaard
Patent: WO2010/84185 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
in N,N-dimethyl-formamide; mineral oil
反应条件
1: 6-bromo-1-methyl-1H-indole With sec.-butyllithium in diethyl ether T=-78°C; 2: methyl chloroformate in diethyl ether T=-78 - -20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 2 p. 125 - 128
反应条件
1.1: NaH / dimethylformamide / 25 °C 2.1: sBuLi / diethyl ether / -78 °C 2.2: diethyl ether / -78 - -20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 2 p. 125 - 128
反应条件
1: NaOH / methanol; H2O / 8 h / Heating 2: triethylamine; diphenylphosphorazidate / benzene / 1 h / 20 °C 3: chlorobenzene / 1 h / Heating View Scheme
参考文献
Rigby, James H.; Burke, Patrick J.
Heterocycles, 2006 , vol. 67, # 2 p. 643 - 653
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20 - 120°C; 3.5 h;
参考文献
Sun, Guangxing; Fecko, Christopher J.; Nicewonger, Robert B.; Webb, Watt W.; Begley, Tadhg P.
Organic Letters, 2006 , vol. 8, # 4 p. 681 - 683
反应条件
in tetrahydrofuran; hexane; ethyl acetate
参考文献
Pfizer Inc.
Patent: US6017945 A1, 2000 ;
反应条件
methanol; sodium hydroxide; water in tetrahydrofuran T=20°C; 36 h;
参考文献
METHYLGENE, INC.
Patent: WO2005/30704 A1, 2005 ;
Location in patent: Page/Page column 199-200 ;
