4-(N-叔丁氧基羰基氨基甲基)苯甲酸甲酯合成路线 （共 18 条）
反应条件
1: With sodium hydroxide; water in methanol T=60°C; 1 h; 2: With hydrogenchloride in water
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1908752 A1, 2008 ;
Location in patent: Page/Page column 50 ;
反应条件
hydrogenchloride in 1,4-dioxane 1 h;
参考文献
Tamura; Matsushita; Iwama; Harada; Kishimoto; Itoh
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 5 p. 1199 - 1212
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C;
参考文献
Solladie, Nathalie; Walther, Mathieu E.; Herschbach, Haiko; Leize, Emmanuelle; Dorsselaer, Alain Van; Duarte, Teresa M. Figueira; Nierengarten, Jean-Francois
Tetrahedron, 2006 , vol. 62, # 9 p. 1979 - 1987
反应条件
4-(N,N-dimethlyamino)pyridine in methanol
T=20°C; 16 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2005/12280 A1, 2005 ;
Location in patent: Page/Page column 52 ;
WO 2005/012280 A1
反应条件
triethanolamine in dichloromethane
参考文献
Ko, Sung-Bo; Oh, Eu-Gene; Kim, Eon-Kyeom; Kim, Won-Yeob; Choi, Dennis W.; Dugan, Laura L.; Koh, Jae-Young; Won, Moo-Ho; Wie, Myung-Bok
Patent: US2003/220337 A1, 2003 ;
反应条件
C45H59ClNPPd; potassium carbonate in water; tert-butyl alcohol
T=85°C; Suzuki-Miyaura Coupling; 3 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2013 , vol. 15, # 10 p. 2534 - 2537
反应条件
1: 4-[[N-(tert-butyloxycarbonyl)amino]methyl]benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane
0.0833333 h;
2: methanol in dichloromethane
T=20°C; 18 h; Product distribution / selectivity;
参考文献
EVOTEC NEUROSCIENCES GMBH; MADDEN, James; HALLETT, David James; PARKES, Alastair; RAOOF, Ali; WANG, Xialou
Patent: WO2010/20556 A1, 2010 ;
Location in patent: Page/Page column 206-207 ;
WO 2010/020556 A1
反应条件
potassium hydroxide in tetrahydrofuran; water
T=20°C;
参考文献
Gutierrez-Nava, Manuel; Nierengarten, Helene; Masson, Patrick; Van Dorsselaer, Alain; Nierengarten, Jean-Francois
Tetrahedron Letters, 2003 , vol. 44, # 15 p. 3043 - 3046
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; dichloro(cycloocta-1,5-diene)palladium(II) in water; tert-butyl alcohol
T=95°C; Suzuki-Miyaura cross-coupling; 22 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2012 , vol. 14, # 12 p. 3138 - 3141
反应条件
in dichloromethane; water
T=0°C; 2 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1612204 A1, 2006 ;
Location in patent: Page/Page column 40-41 ;
