3 - （二甲氨基）- 1 -苯基 -2-丙烯-1-酮合成路线 （共 43 条）
反应条件
1: 1.) Phosphorus oxychloride, 2.) Sodium perchlorate monohydrate / 1.) anhydr. Dichloromethane, room temp., 20 min; 0 deg C, 10 min, 2.) Dichloromethane/water, 0 deg C, 20 min
2: 62 percent / Sodium sulfide nonahydrate / dimethylformamide; H2O / 2 h / Ambient temperature
3: 62 percent / Pyridine, Hydroxylamine-O-sulfonic acid / ethanol; methanol / 0.5 h / Ambient temperature
View Scheme
参考文献
Lin, Yang-i; Lang, Stanley, A.
Journal of Organic Chemistry, 1980 , vol. 45, # 24 p. 4857 - 4860
反应条件
hydroxylamine hydrochloride; potassium carbonate in ethanol
6 h; Heating;
参考文献
Takeuchi, Naoki; Goto, Kaori; Sasaki, Yuki; Fujita, Takashi; Okazaki, Kohsuke; et al.
Heterocycles, 1992 , vol. 33, # 1 p. 357 - 374
反应条件
pyridine; acetic acid
2 h; Heating;
参考文献
Elghamry, Ibrahim
Synthesis, 2003 , # 15 p. 2301 - 2303
反应条件
hydroxylamine hydrochloride; sodium acetate in ethanol; water
3 h;
参考文献
Al-Qalaf, Fawzia; Abdelkhalik, Mervat Mohammed; Al-Enezi, Amal; Al-Ajmi, Johara Rashed
Heterocycles, 2008 , vol. 75, # 1 p. 145 - 156
反应条件
1: sodium hydroxide / butan-1-ol / 12 h / |Inert atmosphere; |Schlenk technique; |Reflux
2: copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine / 1,4-dioxane / 20 h / 20 - 100 °C / |Inert atmosphere; |Schlenk technique
3: hydrazine hydrate; anhydrous iron chloride; carbon / water / 80 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
反应条件
1,4-diaza-bicyclo[2.2.2]octane in ethanol
Reflux;
参考文献
Zheng, Ren-Lin; Zeng, Xiu-Xiu; He, Hai-Yun; He, Jun; Yang, Sheng-Yong; Yu, Luo-Ting; Yang, Li
Synthetic Communications, 2012 , vol. 42, # 10 p. 1521 - 1531
反应条件
1: aq. NH2OH*HCl
2: ClSO3H / 110 - 113 °C
4: aq. EtOH / 18 h / 25 °C
View Scheme
参考文献
Wilson,B.D.; Burness,D.M.
Journal of Organic Chemistry, 1966 , vol. 31, p. 1565 - 1569
反应条件
cerium(III) chloride heptahydrate; ammonium acetate; sodium iodide in isopropyl alcohol
Reflux;
参考文献
Kantevari, Srinivas; Patpi, Santhosh Reddy; Sridhar, Balasubramanian; Yogeeswari, Perumal; Sriram, Dharmarajan
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1214 - 1217
反应条件
copper (II) acetate monohydrate; hydrazine hydrate in N,N-dimethyl-formamide
regioselective reaction;
参考文献
Raghunadh, Akula; Meruva, Suresh Babu; Mekala, Ramamohan; Raghavendra Rao; Krishna, Thalishetti; Gangadhara Chary; Vaikunta Rao; Syam Kumar
Tetrahedron Letters, 2014 , vol. 55, # 18 p. 2986 - 2990
反应条件
chitosan-grafted-poly(4-vinylpyridine) beads in ethanol
3 h; Reflux;
参考文献
Khalil, Khaled D.; Al-Matar, Hamad M.
Molecules, 2013 , vol. 18, # 5 p. 5288 - 5305
