N-甲基-N-(2-羟乙基)-4-氨基苯醛合成路线 （共 9 条）
反应条件
potassium carbonate in dimethyl sulfoxide a) RT, 5 d, b) 60 deg C, 5 h;
参考文献
Lupo, Donald; Ringsdorf, Helmut; Schuster, Andreas; Seitz, Markus
Journal of the American Chemical Society, 1994 , vol. 116, # 23 p. 10498 - 10506
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=5°C; Vilsmaeir reaction; 0.5 h; 2: N-methyl-N-phenyl-N-(2-hydroxyethyl)amine T=20°C; 3 h;
参考文献
BECTON, DICKINSON AND COMPANY
Patent: WO2006/25887 A2, 2006 ;
Location in patent: Page/Page column 21; 44-45 ;
参考文献
DE711665 , ;
DRP/DRBP Org.Chem.
US2141090 , ;
反应条件
1: benzene; phosphorus oxychloride 2: aq.-ethanolic sodium carbonate View Scheme
参考文献
DE711665 , ;
DRP/DRBP Org.Chem.
US2141090 , ;
反应条件
hydrogenchloride; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; acetic acid 1.) from 100 deg C to 105 deg C, 2 h, 2.) reflux, 30 min; Yield given. Multistep reaction;
参考文献
Polish Journal of Chemistry, , vol. 68, # 11 p. 2153 - 2166
反应条件
(i) POCl3, (ii) aq. NaOH, EtOH; Multistep reaction;
参考文献
Journal of the Chemical Society, , p. 883 - 887
反应条件
tetrachloromethane; triphenylphosphine in chloroform T=55°C; 1 h; Inert atmosphere;
参考文献
Mudd, Sarah R.; Trubetskoy, Vladimir S.; Blokhin, Andrei V.; Weichert, Jamey P.; Wolff, Jon A.
Bioconjugate Chemistry, 2010 , vol. 21, # 7 p. 1183 - 1189
反应条件
piperidine T=100 - 120°C; 3 h;
参考文献
Gao, Fang; Hu, Nvdan; Xie, Ting; Cheng, Zhibin; Yang, Long; Liu, Xiaojiao; Li, Zedong; Wang, Xinfu; Li, Hongru; Li, Xueming
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 70, # 5 p. 1006 - 1012
