3-(氯甲基)-5-苯基-1,2,4-恶二唑合成路线 （共 5 条）
反应条件
1: in dichloromethane T=20°C; 0.5 h; 2: With triethylamine in dichloromethane 0.5 h;
参考文献
Chiesi Farmaceutici S.p.A.; AMARI, Gabriele; Pesenti, Cristina; Bossolo, Stefano
Patent: US2013/172302 A1, 2013 ;
Location in patent: Paragraph 0136; 0137; 0138 ;
反应条件
triethanolamine in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; toluene
反应条件
in toluene 6 h; Reflux;
参考文献
CHIESI FARMACEUTICI S.P.A.; AMARI, Gabriele; PESENTI, Cristina; BOSSOLO, Stefano
Patent: WO2013/98145 A1, 2013 ;
Location in patent: Page/Page column 38-39 ;
反应条件
1: With potassium carbonate in 1,4-dioxane Acylation; 2: in xylene Cyclization; Heating; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 5 p. 995 - 1010
反应条件
1: triethylamine / dichloromethane / 1 h / 20 °C 2: toluene / 6 h / |Reflux View Scheme
