3,4-二氢-7-(4-氯丁氧基)-2(1H)-喹啉酮合成路线 （共 9 条）
反应条件
potassium carbonate; polyethylene glycol-400 in water; acetone T=20°C; 15.1667 - 16.1667 h;
参考文献
UNICHEM LABORATORIES LIMITED
Patent: WO2007/94009 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium carbonate in propan-1-ol 8 - 10 h; Heating / reflux; Product distribution / selectivity;
参考文献
Naddaka, Vladimir; Brand, Michael; Davidi, Guy; Klopfer, Eyal; Gribun, Irina; Arad, Oded; Kaspi, Joseph
Patent: US2006/79689 A1, 2006 ;
Location in patent: Page/Page column 9; 10 ;
反应条件
sodium hydroxide in isobutyramide T=36 - 40°C; 4 h; Product distribution / selectivity;
参考文献
US2006/258869 A1, ;
Page/Page column 3; 5 ;
反应条件
potassium carbonate; tetrabutylammomium bromide in water T=90°C; 2 - 3 h; Product distribution / selectivity;
参考文献
WO2007/118923 A1, ;
Page/Page column 7-8 ;
反应条件
potassium carbonate in propan-1-ol 10 h; Heating / reflux;
参考文献
US2007/213535 A1, ;
Page/Page column 4 ;
反应条件
potassium carbonate in water T=90 - 95°C; 4 h;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2004/63162 A1, 2004 ;
Location in patent: Page 11 ;
反应条件
1: 7-(4-chlorobutoxy)-3,4-dihydroquinolin-2(1H)-one With sodium iodide in N,N-dimethyl-formamide T=70 - 80°C; 1 h; 2: 1-(2,3-dichloro-phenyl)-piperazine With potassium carbonate in N,N-dimethyl-formamide T=70 - 80°C; 4 h;
参考文献
UNICHEM LABORATORIES LIMITED
Patent: WO2007/94009 A1, 2007 ;
Location in patent: Page/Page column 7-8 ;
反应条件
potassium carbonate; sodium iodide; tetrabutylammomium bromide in acetonitrile T=20°C; Heating / reflux; Product distribution / selectivity;
参考文献
US2006/258869 A1, ;
Page/Page column 3; 5 ;
反应条件
N-ethyl-N,N-diisopropylamine; sodium iodide in pentan-1-ol T=100°C; 5 h; Heating / reflux; Product distribution / selectivity;
参考文献
FERMION OY
Patent: WO2007/118923 A1, 2007 ;
Location in patent: Page/Page column 8-9 ;
