N,N-二乙基-4-氨基苯甲醛合成路线 （共 64 条）
反应条件
1: cis-1-bromo-2-ethoxyethylene With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.666667 h; 2: 4-[N,N-bis(ethyl)amino]benzaldehyde in tetrahydrofuran; pentane T=-78°C; 2 h;
参考文献
Lemercier, Gilles; Martineau, Cecile; Mulatier, Jean-Christophe; Wang, Irene; Stephan, Olivier; Baldeck, Patrice; Andraud, Chantal
New Journal of Chemistry, 2006 , vol. 30, # 11 p. 1606 - 1613
反应条件
1: 41.67 g / NH4OAc / toluene; pyridine / 48 h / Heating 2: DIBAL / toluene / 0 deg C -> RT, 3 h 3: 18.1 g / 3N H2SO4 / H2O; methanol; toluene View Scheme
参考文献
Kim, Eunha; Koh, Minseob; Lim, Byung Joon; Park, Seung Bum
Journal of the American Chemical Society, 2011 , vol. 133, # 17 p. 6642 - 6649
反应条件
oxalic acid; lithium diisopropyl amide 1.) cyclohexane, 0 deg C, 10 min, 2.) cyclohexane-Et2O, -70 deg C -> RT, 3.) THF-H2O, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Chao, Herbert S.-I.
Synthetic Communications, 1988 , vol. 18, # 14 p. 1641 - 1650
参考文献
Chao, Herbert S.-I.
Synthetic Communications, 1988 , vol. 18, # 14 p. 1641 - 1650
反应条件
ammonium acetate in pyridine; toluene 48 h; Heating; Yield given;
参考文献
Chao, Herbert S.-I.
Synthetic Communications, 1988 , vol. 18, # 14 p. 1641 - 1650
参考文献
Sachs,F.; Michaelis
Chemische Berichte, 1906 , vol. 39, p. 2166
反应条件
1: chloroform; piperidine
2: aqueous hydrochloric acid
View Scheme
参考文献
Wiley et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 5102,5104
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 4 h; Inert atmosphere;
参考文献
Gegout, Aline; Nierengarten, Jean-Francois; Delavaux-Nicot, Beatrice; Duhayon, Carine; Saquet, Alix; Listorti, Andrea; Belbakra, Abdelhalim; Chiorboli, Claudio; Armaroli, Nicola
Chemistry - A European Journal, 2009 , vol. 15, # 35 p. 8825 - 8833
参考文献
Tipson
Journal of the American Chemical Society, 1945 , vol. 67, p. 507,508, 510
反应条件
methylamine in acetic acid
参考文献
Levshin, I. B.; Tsurkan, A. A.; V'yunov, K. A.; Ginak, A. I.
J. Appl. Chem. USSR (Engl. Transl.), 1983 , vol. 56, # 7 p. 1453 - 1455,1361 - 1362
