4,5-二氯-1H-吡咯-2-羧酸甲酯合成路线 （共 10 条）
反应条件
N-chloro-succinimide in tetrahydrofuran T=70°C; 23.5 h;
参考文献
WO2007/138355 A1, ;
Page/Page column 89-90 ;
WO 2007/138355 A1
反应条件
N-chloro-succinimide in tetrahydrofuran T=70°C; 24 h;
参考文献
WO2008/17883 A2, ;
Page/Page column 49 ;
WO 2008/017883 A2
反应条件
sulfuryl dichloride in chloroform 4 h;
参考文献
Smith, Jason A.; Ng, Sarah; White, Jonathon
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 12 p. 2477 - 2482
反应条件
in methanol T=0 - 20°C; 13 h;
参考文献
Cheng, Ping; Clive, Derrick L.J.; Fernandopulle, Shimal; Chen, Zhenhua
Chemical Communications, 2013 , vol. 49, # 6 p. 558 - 560
反应条件
phosphorus pentachloride 1.) 20 min, 160 deg C, 2.) 30 min, 100 deg C; Yields of byproduct given;
参考文献
Effenberger, Franz; Mueller, Wolfgang; Isak, Heinz
Chemische Berichte, 1987 , vol. 120, p. 45 - 54
参考文献
Effenberger, Franz; Mueller, Wolfgang; Isak, Heinz
Chemische Berichte, 1987 , vol. 120, p. 45 - 54
反应条件
1: 22 percent / PCl5 / CH2Cl2 / 20 h / 45 °C 2: 93 percent / 2 - 3 weeks, RT View Scheme
参考文献
Chemische Berichte, , vol. 120, p. 45 - 54
反应条件
1: sulfuryl dichloride / chloroform / 30 h / |Reflux 2: methanol / 13 h / 0 - 20 °C View Scheme
参考文献
Chemical Communications, , vol. 49, # 6 p. 558 - 560
反应条件
1: 56 percent / PCl5 / 1.) 20 min, 160 deg C, 2.) 30 min, 100 deg C 2: 93 percent / 2 - 3 weeks, RT View Scheme
参考文献
Chemische Berichte, , vol. 120, p. 45 - 54
反应条件
1: With sodium hydroxide; water
2 h; Heating / reflux;
2: With hydrogenchloride in water
T=0°C;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2007/138355 A1, 2007 ;
Location in patent: Page/Page column 90 ;
WO 2007/138355 A1
