1: 79 percent / 2N aq.NaOH / methanol / 7 h / 50 °C 2: imidazole / dimethylformamide / 21 h / Ambient temperature 3: Na2CO3 / tetrahydrofuran; H2O / 19 h / Ambient temperature 4: 1-chloro-N,N-2-trimethylprop-1-enylamine / CH2Cl2 / 2 h / Ambient temperature 5: Cu2I2 / diethyl ether / 1.5 h / -60 - 0 °C 6: tetrahydrofuran / 1.) -7 deg C to 0 deg C, 2.) r.t., 3 h 7: NaOAc / acetic acid / 2.5 h / 50 - 55 °C 8: 72.8 percent / Bu4NF*3H2O / tetrahydrofuran / 1.)15 h, r.t., 2.)2 h, 55 deg C View Scheme

1: With methanol; potassium hydroxide T=20 - 30°C; 2: With hydrogenchloride in water pH=2.0;