4-氯-1H-吡咯-2-羧酸甲酯合成路线 （共 7 条）
反应条件
in methanol T=20°C; 1 h;
参考文献
AMBIT BIOSCIENCES CORPORATION; ABRAHAM, Sunny; CHAO, Qi; HADD. Michael, J.; HOLLADAY, Mark, W.; LIU, Gang; NAMBU, Mitchell, D.; SETTI, Eduardo
Patent: WO2010/2472 A1, 2010 ;
Location in patent: Page/Page column 168 ;
WO 2010/002472 A1
参考文献
WO2007/138355 A1, ;
Page/Page column 89 ;
WO 2007/138355 A1
参考文献
Smith, Jason A.; Ng, Sarah; White, Jonathon
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 12 p. 2477 - 2482
反应条件
in chloroform 72 h; Ambient temperature;
参考文献
Polyak, F. D.; Eremeev, A. V.; Gavars, M. P.; Gaukhman, A. P.; Mazheika, I. B.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , p. 733 - 735
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 7 p. 894 - 896
反应条件
in diethyl ether 48 h; Ambient temperature;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , p. 733 - 735
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 24, # 7 p. 894 - 896
反应条件
N-chloro-succinimide in tetrahydrofuran T=70°C; 23.5 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2007/138355 A1, 2007 ;
Location in patent: Page/Page column 89-90 ;
WO 2007/138355 A1
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 4 h / 85 °C
2: 91 percent / 6 N NaOH / ethanol / 2 h / Heating
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
