2,4-二甲基-5-氨基吡啶合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=3102.9 Torr; 2 h;
参考文献
Wang, Yuqiang; Liu, Mao-Chin; Lin, Tai-Shun; Sartorelli, Alan C.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3667 - 3671
反应条件
hydrogen; palladium in ethanol
参考文献
US6610692 B1, ;
US 6610692 B1
反应条件
1: 18 percent / fuming sulfuric acid, potassium nitrate / 16 h / 100 - 120 °C 2: 98 percent / H2 / 5percent Pd/C / ethanol / 2 h / 3102.9 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 20 p. 3667 - 3671
反应条件
sulfuric acid; sodium nitrite a.) 0 deg C, 15 min, b.) reflux, 15 min;
参考文献
Wang, Yuqiang; Liu, Mao-Chin; Lin, Tai-Shun; Sartorelli, Alan C.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3667 - 3671
反应条件
sulfuric acid Diazotization.und anschliessenden Erwaermen;
参考文献
Furukawa
Yakugaku Zasshi, 1956 , vol. 76, p. 900
Chem.Abstr., 1957 , p. 2770
参考文献
Furukawa
Yakugaku Zasshi, 1956 , vol. 76, p. 900
Chem.Abstr., 1957 , p. 2770
反应条件
hydrogen bromide; dihydrogen peroxide in water T=10°C; 2 h;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4764 - 4768
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite in water 1.) 10 deg C, 2.) room temp., 30 min, 3.) 80 deg C, 20 min;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 626 - 633
反应条件
1: 70 percent / HBr, H2O2 / H2O / 2 h / 10 °C
2: 1.) sodium nitrite, HCl; 2.) KI / 1.) H2O, 0 deg C; 2.) H2O, 30 min at RT then 1 hr at 60 deg C
View Scheme
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4764 - 4768
反应条件
1: 62 percent / toluene / 2 h / 100 °C
2: 1.) nitrosyl chloride, anhydrous potassium acetate, 2.) anhydrous sodium carbonate / 1.) acetic anhydride, acetic acid, 30 min, 2.) benzene, 2 h, reflux
View Scheme
参考文献
Chapman, David; Hurst, Jim
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2398 - 2404
