5-甲基-1H-吡咯-2-甲醛合成路线 （共 17 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate 0.333333 h; 2: 2-methyl-1H-pyrrole in 1,2-dichloro-ethane 0.25 h; Heating / reflux; 3: With sodium acetate in 1,2-dichloro-ethane T=80°C; 0.333333 h;
参考文献
Bristol Myers Squibb Company
Patent: US6982265 B1, 2006 ;
Location in patent: Page/Page column 26 ;
参考文献
Tomlinson, John T.; Park, Gyungse; Misenheimer, Jacob A.; Kucera, Gregory L.; Hesp, Kevin; Manderville, Richard A.
Organic Letters, 2006 , vol. 8, # 21 p. 4951 - 4954
反应条件
1: 75 percent / LiAlH4 / tetrahydrofuran 2: 70 percent / POCl3 View Scheme
参考文献
Organic Letters, , vol. 8, # 21 p. 4951 - 4954
反应条件
1: 34 percent / N,N'-carbonyldiimidazole; NaH / dimethylformamide / 40 °C 2: H2 / Pd/C View Scheme
参考文献
Fitoterapia, , vol. 73, # 1 p. 22 - 27
反应条件
in tetrahydrofuran T=400°C; sealed tube;
参考文献
Tetrahedron, , vol. 45, # 11 p. 3397 - 3414
反应条件
1: 74 percent / acetonitrile 2: 1) NBS; 2) 0.5 N HCl, NaOH / 1) THF, -78 deg C; 2) MeOH, 20 min 3: -78 °C 4: 2) NaOAc / 1) from -78 deg C to RT; 2) water, 15 h, reflux View Scheme
参考文献
Helvetica Chimica Acta, , vol. 71, p. 2053 - 2057
反应条件
sodium acetate 1) from -78 deg C to RT; 2) water, 15 h, reflux; Yield given. Multistep reaction;
参考文献
Helvetica Chimica Acta, , vol. 71, p. 2053 - 2057
反应条件
diethyl ether; ethylmagnesium bromide
参考文献
Justus Liebigs Annalen der Chemie, , vol. 486, p. 33
反应条件
tert.-butyl lithium; sodium acetate Yield given. Multistep reaction;
参考文献
Canadian Journal of Chemistry, , vol. 73, # 5 p. 675 - 684
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 29, # 7 p. 777 - 780
