6-氟-1H-吡咯并[3,2-b]吡啶合成路线 （共 3 条）
反应条件
sodium hydride in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; 2 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy
Patent: WO2013/92940 A1, 2013 ;
Location in patent: Page/Page column 51 ;
反应条件
1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 0 - 20 °C / |Inert atmosphere 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy
Patent: WO2013/92940 A1, 2013 ;
反应条件
1: tin(ll) chloride; hydrogenchloride / ethanol / 1 h / 60 °C 2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 0 - 20 °C / |Inert atmosphere 3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy
Patent: WO2013/92940 A1, 2013 ;
