2, 2'-二硫代二苯甲酸合成路线 （共 163 条）
反应条件
1: pyridine, thionyl chloride / toluene / Heating
2: 38.3 percent / dioxane / 3.5 h / 20 °C
View Scheme
参考文献
Yamada; Niino; Hashimoto; Shuto; Nakamizo; Kubo; Ono; Murayama
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1214 - 1220
反应条件
1: P4S10; pyridine
2: Hg(OAc)2 / acetic acid; CHCl3
3: aq. H2O2 / acetic acid
View Scheme
参考文献
Salvetti, Raul; Martinetti, Giovanni; Ubiali, Daniela; Pregnolato, Massimo; Pagani, Giuseppe
Farmaco, 2003 , vol. 58, # 9 p. 995 - 998
参考文献
Maumee Devel. Co.
Patent: US2705242 , 1959 ;
反应条件
1: thionyl chloride
2: 90 percent / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: 1.) thionyl chloride, DMF, 2.) Cl2 gas / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 10 deg C, 20 min
2: SnCl4 / 12 h / Ambient temperature
View Scheme
参考文献
Honek, John F.; Manchini, Michael L.; Belleau, Bernard
Synthetic Communications, 1983 , vol. 13, # 12 p. 977 - 984
反应条件
1: 1.) thionyl chloride, DMF, 2.) Cl2 gas / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 10 deg C, 20 min
2: SnCl4 / 12 h / Ambient temperature
View Scheme
参考文献
Honek, John F.; Manchini, Michael L.; Belleau, Bernard
Synthetic Communications, 1983 , vol. 13, # 12 p. 977 - 984
反应条件
1: 89 percent / 1,3-diisopropylcarbodiimide / tetrahydrofuran; propan-2-ol / 4 h / 25 °C
2: dimethylformamide / 25 °C
3: tris-(2-carboxyethyl)phosphine hydrochloride; triethylamine / dimethylformamide; H2O / 25 °C
View Scheme
参考文献
Srivastava, Pratibha; Schito, Marco; Fattah, Rasem J.; Hara, Toshiaki; Hartman, Tracy; Buckheit Jr., Robert W.; Turpin, Jim A.; Inman, John K.; Appella, Ettore
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 24 p. 6437 - 6450
反应条件
1: 89 percent / 1,3-diisopropylcarbodiimide / tetrahydrofuran; propan-2-ol / 4 h / 25 °C
2: dimethylformamide / 25 °C
3: tris-(2-carboxyethyl)phosphine hydrochloride; triethylamine / dimethylformamide; H2O / 25 °C
View Scheme
参考文献
Srivastava, Pratibha; Schito, Marco; Fattah, Rasem J.; Hara, Toshiaki; Hartman, Tracy; Buckheit Jr., Robert W.; Turpin, Jim A.; Inman, John K.; Appella, Ettore
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 24 p. 6437 - 6450
反应条件
1: 89 percent / 1,3-diisopropylcarbodiimide / tetrahydrofuran; propan-2-ol / 4 h / 25 °C
2: dimethylformamide / 25 °C
3: tris-(2-carboxyethyl)phosphine hydrochloride; triethylamine / dimethylformamide; H2O / 25 °C
View Scheme
参考文献
Srivastava, Pratibha; Schito, Marco; Fattah, Rasem J.; Hara, Toshiaki; Hartman, Tracy; Buckheit Jr., Robert W.; Turpin, Jim A.; Inman, John K.; Appella, Ettore
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 24 p. 6437 - 6450
反应条件
1: bis (2-carboxyphenyl)-disulfide With sulfuric acid
T=25°C; 1 h;
2: toluene T=20 - 25°C; 2 h;
参考文献
San-Apro Limited
Patent: US8329771 B2, 2012 ;
Location in patent: Page/Page column 23 ;
