4-甲氧基-3-硝基甲苯合成路线 （共 59 条）
反应条件
1: 4-methyl-2-nitrophenol With sodium hydroxide in water 2: dimethyl sulfate With tetrabutylammomium bromide in dichloromethane; water T=10 - 25°C; 10 - 12 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.
Patent: WO2006/40650 A1, 2006 ;
Location in patent: Page/Page column 31-32 ;
WO 2006/040650 A1
反应条件
sulfuric acid; nitric acid 0.25 h; cooling;
参考文献
Dinda, Biswanath; De, Utpal Chandra; Achari, Basudev; Arima, Shiho; Sato, Nariko; Harigaya, Yoshihiro
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 6 p. 1514 - 1518
反应条件
dinitrogen tetraoxide in dichloromethane T=-30°C; Nitration; demethylation; 1 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 34, # 9 p. 1322 - 1330
反应条件
TNM; tetrabutylammonium salt of trinitromethane in acetonitrile T=25 - 30°C; 7 h; Irradiation; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 109, p. 7824
反应条件
air; nitrogen(II) oxide in acetonitrile 2 h; Ambient temperature;
参考文献
Journal of Chemical Research, Synopses, , # 7 p. 284 - 285
反应条件
NOBF4 in acetonitrile T=25°C; 0.5 h;
参考文献
Journal of Organic Chemistry, , vol. 59, # 19 p. 5573 - 5586
反应条件
potassium carbonate in N,N-dimethyl-formamide 12 h; Ambient temperature;
参考文献
Avasthi; Chandra; Rawat; Bhakuni
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 5 p. 437 - 440
反应条件
nitric acid in acetic anhydride T=-40°C;
参考文献
Fischer, Alfred; Fyles, Deborah L.; Henderson, George N.
Journal of the Chemical Society, Chemical Communications, 1980 , # 11 p. 513 - 514
反应条件
nitric acid in acetic anhydride T=-10°C; 4 h;
参考文献
Doklady Chemistry, , vol. 258, p. 217 - 220
Dokl. Akad. Nauk SSSR Ser. Khim., , vol. 258, # 2 p. 368 - 371
反应条件
nitric acid in acetic anhydride T=-10°C; 4 h;
参考文献
Doklady Chemistry, , vol. 258, p. 217 - 220
Dokl. Akad. Nauk SSSR Ser. Khim., , vol. 258, # 2 p. 368 - 371
