(2S)-alpha,alpha-二苯基-1-(苯基甲基)-2-吡咯烷甲醇合成路线 （共 16 条）
反应条件
in tetrahydrofuran T=20°C; 12 h;
参考文献
Hosoda, Naoya; Kamito, Hideaki; Takano, Miki; Takebe, Yoshitaka; Yamaguchi, Yoshitaka; Asami, Masatoshi
Tetrahedron, 2013 , vol. 69, # 6 p. 1739 - 1746
反应条件
magnesium in tetrahydrofuran T=25°C; 12 h;
参考文献
Luis Olivares-Romero; Juaristi, Eusebio
Tetrahedron, 2008 , vol. 64, # 42 p. 9992 - 9998
反应条件
in tetrahydrofuran T=20°C; Grignard reaction; 24 h;
参考文献
Shen, Yongcun; Feng, Xiaoming; Li, Yan; Zhang, Guolin; Jiang, Yaozhong
European Journal of Organic Chemistry, 2004 , # 1 p. 129 - 137
反应条件
potassium carbonate in ethanol Heating;
参考文献
Watanabe, Masami; Soai, Kenso
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 7 p. 837 - 842
反应条件
in diethyl ether 2 h; Heating;
参考文献
Enders, Dieter; Kipphardt, Helmut; Gerdes, Peter; Brena-Valle, Leonardo J.; Bhushan, Vidya
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 8-9 p. 691 - 704
反应条件
in tetrahydrofuran; diethyl ether T=-78 - 20°C;
参考文献
Almansa, Raquel; Guijarro, David; Yus, Miguel
Tetrahedron Asymmetry, 2007 , vol. 18, # 23 p. 2828 - 2840
反应条件
1: bromobenzene With iodine; magnesium in tetrahydrofuran Reflux; 2: (S)-methyl 1-benzylpyrrolidine-2-carboxylate hydrochloride in tetrahydrofuran T=0 - 20°C;
参考文献
Sparr, Christof; Tanzer, Eva-Maria; Bachmann, Julia; Gilmour, Ryan
Synthesis, 2010 , # 8 art. no. T20109SS, p. 1394 - 1397
反应条件
1.1: Et3N / dimethylformamide / 0.08 h / 20 °C 1.2: K2CO3; NaI / dimethylformamide / 50 °C 2.1: 72 percent / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Shen, Yongcun; Feng, Xiaoming; Li, Yan; Zhang, Guolin; Jiang, Yaozhong
European Journal of Organic Chemistry, 2004 , # 1 p. 129 - 137
反应条件
1: thionylchloride / -30 deg C to Rt, reflux, 1 h 2: triethylamine / ethanol / 4 h / Heating 3: 75 percent / diethyl ether / 2 h / Heating View Scheme
参考文献
Enders, Dieter; Kipphardt, Helmut; Gerdes, Peter; Brena-Valle, Leonardo J.; Bhushan, Vidya
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 8-9 p. 691 - 704
反应条件
1: triethylamine / ethanol / 4 h / Heating 2: 75 percent / diethyl ether / 2 h / Heating View Scheme
参考文献
Enders, Dieter; Kipphardt, Helmut; Gerdes, Peter; Brena-Valle, Leonardo J.; Bhushan, Vidya
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 8-9 p. 691 - 704
