(R)-2-(4-溴苯基)吡咯烷合成路线 （共 5 条）
反应条件
hydrogenchloride in 1,4-dioxane; methanol T=20°C; 0.5 h; Inert atmosphere;
参考文献
NOVARTIS AG; LELETI, Rajender, Reddy; LIU, Yugang; PRASHAD, Mahavir
Patent: WO2011/103263 A2, 2011 ;
Location in patent: Page/Page column 59-60 ;
反应条件
1: With hydrogenchloride in 1,4-dioxane; methanol T=20°C; 0.5 h; Inert atmosphere; 2: With sodium hydroxide in water pH=13;
参考文献
Reddy, Leleti Rajender; Prashad, Mahavir
Chemical Communications, 2010 , vol. 46, # 2 p. 222 - 224
反应条件
1.1: titanium tetraethoxide / tetrahydrofuran / 48 h / 65 °C / Inert atmosphere 2.1: lithium triethylborohydride / tetrahydrofuran / 3 h / -78 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C 4.2: pH ~ 13 View Scheme
参考文献
NOVARTIS AG; LELETI, Rajender, Reddy; LIU, Yugang; PRASHAD, Mahavir
Patent: WO2011/103263 A2, 2011 ;
反应条件
1.1: lithium triethylborohydride / tetrahydrofuran / 3 h / -78 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C 3.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C 3.2: pH ~ 13 View Scheme
参考文献
NOVARTIS AG; LELETI, Rajender, Reddy; LIU, Yugang; PRASHAD, Mahavir
Patent: WO2011/103263 A2, 2011 ;
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C 2.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C 2.2: pH ~ 13 View Scheme
参考文献
NOVARTIS AG; LELETI, Rajender, Reddy; LIU, Yugang; PRASHAD, Mahavir
Patent: WO2011/103263 A2, 2011 ;
