2-(1-羟基氨基乙基)-苯并噻吩合成路线 （共 5 条）
反应条件
pyridine; hydrogenchloride; borane-pyridine complex; hydroxylamine hydrochloride 1.) ethanol, RT, overnight, 2.) ethanol, RT, 4 h; Yield given. Multistep reaction;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SATYANARAYANA, Komati
Patent: WO2011/36680 A2, 2011 ;
反应条件
hydrogenchloride; n-butyllithium 1) ether, hexane, -20 deg C, 1 h, 2) THF, ether, -40 deg C, 20 min, 3) ethanol, RT, 1 h; Multistep reaction;
参考文献
Basha, Anwer; Ratajczyk, James D.; Brooks, Dee W.
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3783 - 3786
反应条件
1: in tetrahydrofuran T=20°C; 16 h; 2: With water in tetrahydrofuran 0.5 h; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 73, # 5 p. 2028 - 2031
反应条件
1: in water; ethyl acetate T=20°C; 1 h; 2: With hydrogenchloride in water; ethyl acetate T=25°C; Product distribution / selectivity;
参考文献
US2009/286996 A1, ;
Page/Page column 4 ;
反应条件
T=135 - 140°C; 2 h; Product distribution / selectivity;
参考文献
WO2011/36680 A2, ;
Page/Page column 20 ;
