2-(3-(甲基硫代)苯基)乙胺合成路线 （共 12 条）
反应条件
trifluoroacetic acid T=20°C; 0.166667 h;
参考文献
Augelli-Szafran, Corinne Elizabeth; Boehme, Thomas; Schwarz, Roy Douville
Patent: US2003/220335 A1, 2003 ;
Location in patent: Page/Page column 3-4; 6 ;
反应条件
1: SOCl2 / benzene / 48 h / 20 °C 2: 22.9 g / 18-crown-6 / acetonitrile / 48 h / 20 °C 3: 33 percent / Raney nickel / methanol / 48 h / 20 °C 4: 99 percent / CF3CO2H / 0.17 h / 20 °C View Scheme
参考文献
Boehme, Thomas M.; Augelli-Szafran, Corinne E.; Hallak, Hussein; Pugsley, Thomas; Serpa, Kevin; Schwarz, Roy D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3094 - 3102
反应条件
1: 22.9 g / 18-crown-6 / acetonitrile / 48 h / 20 °C 2: 33 percent / Raney nickel / methanol / 48 h / 20 °C 3: 99 percent / CF3CO2H / 0.17 h / 20 °C View Scheme
参考文献
Boehme, Thomas M.; Augelli-Szafran, Corinne E.; Hallak, Hussein; Pugsley, Thomas; Serpa, Kevin; Schwarz, Roy D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3094 - 3102
反应条件
1: 33 percent / Raney nickel / methanol / 48 h / 20 °C 2: 99 percent / CF3CO2H / 0.17 h / 20 °C View Scheme
参考文献
Boehme, Thomas M.; Augelli-Szafran, Corinne E.; Hallak, Hussein; Pugsley, Thomas; Serpa, Kevin; Schwarz, Roy D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3094 - 3102
反应条件
1: 94 percent / aq. KOH / ethanol; H2O / 1 h / -5 - 0 °C 2: 42 percent / LiAlH4 / tetrahydrofuran / 20 h / Ambient temperature View Scheme
参考文献
Euerby, Melvin R.; Waigh, Roger D.
Journal of Chemical Research, Miniprint, 1987 , # 2 p. 527 - 553
反应条件
trichlorophosphate 0.5 h; Heating;
参考文献
Euerby, Melvin R.; Waigh, Roger D.
Journal of Chemical Research, Miniprint, 1987 , # 2 p. 527 - 553
反应条件
1: toluene / 2 h / Heating 2: 75 percent / TFA / toluene / 5 h / Heating 3: NiCl2*6H2O, NaBH4 / methanol / Ambient temperature View Scheme
参考文献
Euerby, Melvin R.; Waigh, Roger D.
Journal of Chemical Research, Miniprint, 1987 , # 2 p. 527 - 553
参考文献
Euerby, Melvin R.; Waigh, Roger D.
Journal of Chemical Research, Miniprint, 1987 , # 2 p. 527 - 553
参考文献
Euerby, Melvin R.; Waigh, Roger D.
Journal of Chemical Research, Miniprint, 1987 , # 2 p. 527 - 553
参考文献
Boehme, Thomas M.; Augelli-Szafran, Corinne E.; Hallak, Hussein; Pugsley, Thomas; Serpa, Kevin; Schwarz, Roy D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3094 - 3102
