(1S,2R,3S,5R)-2-[(苄氧甲基)-6-氧杂二环[3.1.0]己-3-醇合成路线 （共 17 条）
反应条件
1.1: 85 percent / NaH / dimethylformamide 2.1: 80 percent / lithium bistrimethylsilylamide / tetrahydrofuran / 20 °C 3.1: 1,1'-thiocarbonyldiimidazole / tetrahydrofuran 3.2: nBu3SnH; AIBN / toluene / Heating 3.3: DDQ / CH2Cl2; H2O View Scheme
参考文献
Ruediger, Edward; Martel, Alain; Meanwell, Nicholas; Solomon, Carola; Turmel, Brigitte
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 739 - 742
反应条件
1: NaH, Bu4NI / dimethylformamide 2: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 3: 82 percent / TEA, DMAP / CH2Cl2 4: Dess-Martin reagent, t-BuOH / CH2Cl2 View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
1: NaH, Bu4NI / dimethylformamide 2: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 3: 82 percent / TEA, DMAP / CH2Cl2 4: Dess-Martin reagent, t-BuOH / CH2Cl2 5: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 6: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
1: NaH, Bu4NI / dimethylformamide 2: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 3: 82 percent / TEA, DMAP / CH2Cl2 4: Dess-Martin reagent, t-BuOH / CH2Cl2 5: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 6: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C 7: 89 percent / BCl3 / CH2Cl2 / -78 °C View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
1: NaH, Bu4NI / dimethylformamide 2: 60 percent / LiH / dimethylformamide / 2 h / 125 °C View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
1: NaH, Bu4NI / dimethylformamide 2: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 3: 82 percent / TEA, DMAP / CH2Cl2 4: Dess-Martin reagent, t-BuOH / CH2Cl2 5: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
1: NaH, Bu4NI / dimethylformamide 2: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 3: 82 percent / TEA, DMAP / CH2Cl2 View Scheme
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
