反式-3-(2,3,4-三甲氧基苯基)-2-丙烯酸合成路线 (共 15 条)
反应条件
1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(N,N-dimethylamino)pyridine, imidazole / dimethylformamide / 3 h / Ambient temperature 2: 4 N aq. NaOH / methanol / 2 h / 60 °C View Scheme
参考文献
Jacobson; Gallo-Rodriguez; Melman; Fischer; Maillard; Van Bergen; Van Galen; Karton
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1333 - 1342
反应条件
sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 1) dioxane, H2O, 2) dioxane, H2O, reflux; Multistep reaction;
参考文献
Shimada, Junichi; Koike, Nobuaki; Nonaka, Hiromi; Shiozaki, Shizuo; Yanagawa, Koji; Kanda, Tomoyuki; Kobayashi, Hiroyuki; Ichimura, Michio; Nakamura, Joji; Kase, Hiroshi; Suzuki, Fumio
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2349 - 2352
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5543415 A1, 1996 ;
反应条件
sulfuric acid 12 h; Heating;
参考文献
Journal of Chemical & Engineering Data, , vol. 33, # 4 p. 534 - 537
反应条件
thionyl chloride in chloroform
T=0°C; 0.5 h;
参考文献
Ohtaka; Kanazawa; Ito; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4124 - 4129