1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 0.583333 h; 2: 4-cyano-2-hydroxymethylpyridine in dichloromethane T=-78°C; 2.08333 h; 3: With triethylamine in dichloromethane T=-55 - 20°C; 2.25 h;

1: 40.01 g / 18 h / Ambient temperature 2: ethanol; H2O / 0.5 h / 48 - 50 °C 3: 96 percent / m-chloroperbenzoic acid / CHCl3 / 4 h / Ambient temperature 4: 63 percent / Heating 5: 68 percent / aq. H2SO4 / tetrahydrofuran / 20 h / Heating 6: 71 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme

1: 96 percent / m-chloroperbenzoic acid / CHCl3 / 4 h / Ambient temperature 2: 63 percent / Heating 3: 68 percent / aq. H2SO4 / tetrahydrofuran / 20 h / Heating 4: 71 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme

1: 63 percent / Heating 2: 68 percent / aq. H2SO4 / tetrahydrofuran / 20 h / Heating 3: 71 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme

1: ethanol; H2O / 0.5 h / 48 - 50 °C 2: 96 percent / m-chloroperbenzoic acid / CHCl3 / 4 h / Ambient temperature 3: 63 percent / Heating 4: 68 percent / aq. H2SO4 / tetrahydrofuran / 20 h / Heating 5: 71 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme

1: 68 percent / aq. H2SO4 / tetrahydrofuran / 20 h / Heating 2: 71 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme

in isopropyl alcohol T=40 - 45°C;