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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2,5-二碘吡啶
合成路线
（共 12 条）
624-28-2
2,5-二溴吡啶
→
反应条件
116195-81-4
2,5-二碘吡啶
反应条件
1: With nBu4ZnLi2*TMEDA in toluene T=20°C; 2 h; Inert atmosphere; 2: With iodine in tetrahydrofuran; toluene T=20°C; 18 h; Inert atmosphere; chemoselective reaction;
参考文献
Chau, Nguyet Trang Thanh; Meyer, Maxime; Komagawa, Shinsuke; Chevallier, Floris; Fort, Yves; Uchiyama, Masanobu; Mongin, Florence; Gros, Philippe C.
Chemistry - A European Journal, 2010 , vol. 16, # 41 p. 12425 - 12433
73290-22-9
2-溴-5-碘吡啶
→
反应条件
116195-81-4
2,5-二碘吡啶
反应条件
acetyl chloride; potassium iodide in acetonitrile 24 h; Heating;
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
20511-12-0
2-氨基-5-碘吡啶
→
反应条件
116195-81-4
2,5-二碘吡啶
反应条件
hydrogen iodide; sodium nitrite
参考文献
Verslag van de Gewone Vergadering van de Afdeling Natuurkunde, Koninklijke Nederlandse Akademie van Wetenschappen, vol. 36, p. 517
Chem. Zentralbl., , vol. 98, # II p. 2198
624-28-2
2,5-二溴吡啶
→
反应条件
73290-22-9
2-溴-5-碘吡啶
+
116195-81-4
2,5-二碘吡啶
+
223463-13-6
5-溴-2-碘吡啶
反应条件
1: With nBu4ZnLi2*TMEDA in toluene T=20°C; 1 h; Inert atmosphere; 2: With iodine in tetrahydrofuran; toluene 18 h; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 41 p. 12425 - 12433
109-09-1
2-氯吡啶
→
反应条件
153034-86-7
2-氯-4-碘吡啶
+
116195-81-4
2,5-二碘吡啶
反应条件
1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; C6H16N2*2Cl(1-)*Zn(2+) in tetrahydrofuran T=20°C; 2 h; Inert atmosphere; 2: With iodine in tetrahydrofuran Inert atmosphere; regioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 17, # 47 p. 13284 - 13297
504-29-0
2-氨基吡啶
→
反应条件
116195-81-4
2,5-二碘吡啶
反应条件
1: 75 percent / periodic acid dihydrate; iodine; sulfuric acid / acetic acid; H2O / 4 h / 80 °C 2: 77 percent / hydrobromic acid; sodium nitrite; bromine / H2O / -5 - 20 °C 3: 85 percent / potassium iodide; acetyl chloride / acetonitrile / 24 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 58, # 14 p. 2885 - 2890
116195-81-4
2,5-二碘吡啶
→
反应条件
1120-90-7
3-碘吡啶
+
1210053-16-9
反应条件
1: 5 h / 140 °C 2: potassium hydroxide / 23 h / 20 °C View Scheme
参考文献
Shimada, Minami; Sugimoto, Osamu; Sato, Akihiro; Tanji, Ken-Ichi
Heterocycles, 2011 , vol. 83, # 4 p. 837 - 847
116195-81-4
2,5-二碘吡啶
+
68-12-2
N,N-二甲基甲酰胺
→
反应条件
120972-91-0
+
31181-83-6
反应条件
1: 2,5-diiodopyridine With n-butyllithium in hexane; toluene T=-78°C; 2.5 h; Inert atmosphere; 2: N,N-dimethyl-formamide in hexane; toluene T=-78 - -10°C; 1 h; Inert atmosphere; 3: With sodium tetrahydroborate in hexane; toluene T=0°C; 0.5 h;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/312930 A1, 2011 ;
Location in patent: Page/Page column 45 ;
US 20110312930 A1
116195-81-4
2,5-二碘吡啶
→
反应条件
120972-91-0
+
31181-83-6
反应条件
1: With n-butyllithium in hexane; N,N-dimethyl-formamide; toluene T=-78°C; 3.5 h; Inert atmosphere; 2: With sodium tetrahydroborate in hexane; N,N-dimethyl-formamide; toluene T=-10 - 0°C; 0.5 h; 3: With ammonium chloride in hexane; water; N,N-dimethyl-formamide; toluene T=0 - 20°C;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; Härter, Michael; Beck, Hartmut; Ellinghaus, Peter; Berhörster, Kerstin; Greschat, Susanne; Thierauch, Karl-Heinz; Süssmeier, Frank
Patent: US2013/196964 A1, 2013 ;
Location in patent: Paragraph 0972; 0973; 0974; 0975; 0976; 0977 ;
116195-81-4
2,5-二碘吡啶
+
68-12-2
N,N-二甲基甲酰胺
→
反应条件
120972-91-0
+
31181-83-6
反应条件
1: 2,5-diiodopyridine With n-butyllithium in hexane; toluene T=-78°C; 2.5 h; Inert atmosphere; 2: N,N-dimethyl-formamide in hexane; toluene T=-78 - -10°C; 1 h; Inert atmosphere; 3: With sodium tetrahydroborate in hexane; toluene T=0°C; 0.5 h;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/312930 A1, 2011 ;
Location in patent: Page/Page column 45 ;
US 20110312930 A1
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