(R)-2-苄基-琥珀酸 1-苄酯 4-叔丁酯合成路线 （共 8 条）
反应条件
n-butyllithium in tetrahydrofuran T=0°C; 1 h;
参考文献
Plattner; Marcotte; Kleinert; Stein; Greer; Bolis; Fung; Bopp; Luly; Sham; Kempf; Rosenberg; Dellaria; De; Merits; Perun
Journal of Medicinal Chemistry, 1988 , vol. 31, # 12 p. 2277 - 2288
反应条件
1: 1.) sodium hexamethyldisilylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1 h 2: 94 percent / n-butyllithium / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Heitsch; Henning; Kleemann; Linz; Nickel; Ruppert; Urbach; Wagner
Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2788 - 2800
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 20 min, 2.) room temperature, 2 h 2: 1.) sodium hexamethyldisilylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1 h 3: 94 percent / n-butyllithium / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Heitsch; Henning; Kleemann; Linz; Nickel; Ruppert; Urbach; Wagner
Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2788 - 2800
反应条件
1: 1.) sodium hexamethyldisilylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1 h 2: 94 percent / n-butyllithium / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Plattner; Marcotte; Kleinert; Stein; Greer; Bolis; Fung; Bopp; Luly; Sham; Kempf; Rosenberg; Dellaria; De; Merits; Perun
Journal of Medicinal Chemistry, 1988 , vol. 31, # 12 p. 2277 - 2288
反应条件
1: 1.) sodium hexamethyldisilylamide / 1.) THF, -65 deg C, 45 min, 2.) THF, -70 deg C, 3 h 2: 1.) n-butyllithium / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 3 h View Scheme
参考文献
Heitsch; Henning; Kleemann; Linz; Nickel; Ruppert; Urbach; Wagner
Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2788 - 2800
反应条件
n-butyllithium 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Heitsch; Henning; Kleemann; Linz; Nickel; Ruppert; Urbach; Wagner
Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2788 - 2800
反应条件
palladium in methanol
参考文献
Abbott Laboratories
Patent: US5164388 A1, 1992 ;
US 5164388 A
反应条件
trifluoroacetic acid in dichloromethane 1 h; Ambient temperature;
参考文献
Abbott Laboratories
Patent: US4857507 A1, 1989 ;
