N-苄氧羰基-L-苯丙氨酸合成路线 （共 122 条）
反应条件
1: N-benzyloxycarbonyl-L-phenylalanine With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=0°C; 0.5 h; 2: L-phenylalanine in water T=0°C; 0.5 h;
参考文献
Verardo; Gorassini
Journal of Peptide Science, 2013 , vol. 19, # 5 p. 315 - 324
反应条件
1: Et3N; DMAP / acetonitrile / 0.75 h / 20 °C 2: Et3N / acetonitrile; H2O / 1.67 h / 20 °C View Scheme
参考文献
Katritzky, Alan R.; Suzuki, Kazuyuki; Singh, Sandeep K.
Synthesis, 2004 , # 16 p. 2645 - 2652
反应条件
1.1: 4-methyl-morpholine / tetrahydrofuran / 0.08 h / 20 °C 1.2: 0.17 h / -15 °C 2.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.5 h / 0 °C View Scheme
参考文献
Verardo; Gorassini
Journal of Peptide Science, 2013 , vol. 19, # 5 p. 315 - 324
反应条件
1: N-benzyloxycarbonyl-L-phenylalanine With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 2: 2-amino-acetamide hydrochloride With triethylamine in tetrahydrofuran T=20°C; Further stages.;
参考文献
Sutton; Clardy
Journal of the American Chemical Society, 2001 , vol. 123, # 41 p. 9935 - 9946
反应条件
1: NMM / tetrahydrofuran 2: 2.) HCl / 1.) Et2O 3: NaBH4 / ethanol 4: 96 percent / NaOMe / methanol View Scheme
参考文献
He, Meizi; Zhang, Hang; Yao, Xiaojian; Eckart, Michael; Zuo, Elizabeth; Yang, Ming
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 174 - 180
反应条件
(i) N-methylmorpholine, ClCO2iBu, (ii) /BRN= 3727681/, Et3N; Multistep reaction;
参考文献
Kovacs,J.; Rodin,R.L.
Journal of Organic Chemistry, 1968 , vol. 33, # 6 p. 2418 - 2420
反应条件
1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C 2: water / 0.5 h / 0 °C View Scheme
参考文献
Noguchi, Takuya; Tehara, Naoka; Uesugi, Yuki; Jung, Seunghee; Imai, Nobuyuki
Chemistry Letters, 2012 , vol. 41, # 1 p. 42 - 43
反应条件
(i) 4-nitro-phenol, DCC, (ii) /BRN= 3657714/, Et3N, (iii) (saponification); Multistep reaction;
参考文献
Nicolaides,E. et al.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 1 p. 74 - 79
反应条件
1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxy-7-azabenzotriazole / CH2Cl2 / 24 h / 20 °C 2: 223 mg / H2 / Pd/C / methanol / 20 °C View Scheme
参考文献
Veerman, Johan J. N.; Bon, Robin S.; Hue, Bui T. B.; Girones, Daniel; Rutjes, Floris P. J. T.; Van Maarseveen, Jan H.; Hiemstra, Henk
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4486 - 4494
反应条件
ethylenediaminetetraacetic acid; dl-cysteine hydrochloride; papain in water; N,N-dimethyl-formamide T=38°C; 24 h; pH 4.8;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 52, # 9 p. 2309 - 2316
