5-丙酮基-2-甲氧基苯磺酰胺合成路线 （共 5 条）
反应条件
ammonia in tetrahydrofuran; water
参考文献
ZENTIVA, A.S.
Patent: WO2005/75415 A1, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
1: 11.4 g / ClSO3H / 2 h / Ambient temperature 2: conc. aq. NH4OH / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 6 p. 1443 - 1451
反应条件
ammonium acetate; sodium cyanoborohydride in methanol T=20°C; 15 h;
参考文献
Sagratini, Gianni; Angeli, Piero; Buccioni, Michela; Gulini, Ugo; Marucci, Gabriella; Melchiorre, Carlo; Poggesi, Elena; Giardin, Dario
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5800 - 5807
反应条件
1: hydroxylamine hydrochloride / methanol / 5 h / 20 °C 2: hydrogen / 5 palladium on charcoal / methanol / 8 h / 20 °C / 2206.72 Torr View Scheme
参考文献
HAVALDAR, Freddy, H.
Patent: WO2012/101648 A1, 2012 ;
反应条件
2-carboxyethyltriphenylphosphonium perbromide in tetrahydrofuran
T=20°C; 3 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2003/72557 A1, 2003 ;
Location in patent: Page/Page column 45 ;
WO 03/072557 A1
