5-氨基-1,2,3,4-四氢异喹啉合成路线 （共 8 条）
反应条件
sulfuric acid; hydrogen; platinum(IV) oxide in acetic acid Reduction; P=2844.31 Torr; 20 h;
参考文献
Chan, Wai N.; Hadley, Michael S.; Harling, John D.; Herdon, Hugh J.; Orlek, Barry S.; Riley, Graham J.; Stead, Rachel E. A.; Stean, Tania O.; Thompson, Mervyn; Upton, Neil; Ward, Robert W.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2085 - 2094
反应条件
1: concentrated sulfuric acid; potassium nitrate 2: palladium/charcoal; aq.-ethanolic HCl / Hydrogenation View Scheme
参考文献
Yakugaku Zasshi, , vol. 73, p. 666
Chem.Abstr., , p. 7014
反应条件
hydrogenchloride; palladium on activated charcoal Hydrogenation;
参考文献
Yakugaku Zasshi, , vol. 73, p. 666
Chem.Abstr., , p. 7014
反应条件
1: sodium nitrite; sulfuric acid / water 2: hydrogen; palladium on activated charcoal View Scheme
参考文献
Ruel, Rejean; L'Heureux, Alexandre; Thibeault, Carl; Lapointe, Philippe; Martel, Alain; Qiao, Jennifer X.; Hua, Ji; Price, Laura A.; Wu, Qimin; Chang, Ming; Zheng, Joanna; Huang, Christine S.; Wexler, Ruth R.; Rehfuss, Robert; Lam, Patrick Y.S.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6825 - 6828
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C;
参考文献
INTERMUNE, INC.; ARRAY BIOPHARMA INC.
Patent: WO2005/37214 A2, 2005 ;
Location in patent: Page/Page column 121-122 ;
反应条件
1: With sodium hydrogencarbonate in dichloromethane; water
T=0°C; 0.5 h;
2: With N-methylamine hydrochloride; diisopropylamine in dichloromethane; water
参考文献
Wyeth
Patent: US2005/101569 A1, 2005 ;
Location in patent: Page/Page column 31 ;
反应条件
sodium hydrogencarbonate in dichloromethane; water
T=0°C; 0.5 h;
参考文献
Wyeth
Patent: US2008/125454 A1, 2008 ;
Location in patent: Page/Page column 31 ;
反应条件
1: With sodium hydrogencarbonate in dichloromethane; water
T=0°C; 0.5 h;
2: With N-methylamine hydrochloride; diisopropylamine in dichloromethane; water
参考文献
Wyeth
Patent: US2005/101569 A1, 2005 ;
Location in patent: Page/Page column 31 ;
