1-甲基-1H-苯并咪唑-5-甲醇合成路线 （共 9 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h; Cooling with iceInert atmosphere;
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
Location in patent: Paragraph 0242; 0243; 0244; 0245 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.; LINGAM, Prasada, Rao, V., S.; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; BAJPAI, Malini; GULLAPALLI, Srinivas; DAHALE, Dnyaneshwar, Harishchandra; MINDHE, Ajit, Shankar; RATHI, Vijay, Eknath
Patent: WO2011/138657 A1, 2011 ;
Location in patent: Page/Page column 54-55 ;
WO 2011/138657 A1
反应条件
1: 5 palladium on charcoal; hydrogen / methanol / 20 °C 2: 2 h / |Reflux 3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / |Cooling with ice; |Inert atmosphere View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1: 2 h / |Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / |Cooling with ice; |Inert atmosphere View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1: sulfuric acid / 8 h / |Reflux 2: triethylamine / methanol / 1 h / |Cooling with ice 3: 5 palladium on charcoal; hydrogen / methanol / 20 °C 4: 2 h / |Reflux 5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / |Cooling with ice; |Inert atmosphere View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1: triethylamine / methanol / 1 h / |Cooling with ice 2: 5 palladium on charcoal; hydrogen / methanol / 20 °C 3: 2 h / |Reflux 4: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / |Cooling with ice; |Inert atmosphere View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1: sulfuric acid 2: potassium carbonate 3: lithium aluminium tetrahydride View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; LINGAM, Prasada, Rao, V., S.; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; BAJPAI, Malini; GULLAPALLI, Srinivas; DAHALE, Dnyaneshwar, Harishchandra; MINDHE, Ajit, Shankar; RATHI, Vijay, Eknath
Patent: WO2011/138657 A1, 2011 ;
WO 2011/138657 A1
反应条件
1: potassium carbonate 2: lithium aluminium tetrahydride View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; LINGAM, Prasada, Rao, V., S.; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; BAJPAI, Malini; GULLAPALLI, Srinivas; DAHALE, Dnyaneshwar, Harishchandra; MINDHE, Ajit, Shankar; RATHI, Vijay, Eknath
Patent: WO2011/138657 A1, 2011 ;
WO 2011/138657 A1
反应条件
manganese(IV) oxide in acetone 72 h;
参考文献
WO2003/99814 A1, ;
Page 30 ;
