3,5-二碘-THYRO乙酸合成路线 （共 23 条）
反应条件
boron tribromide in dichloromethane T=-78 - 20°C;
参考文献
ST. JUDE CHILDREN'S RESEARCH HOSPITAL; FUJII, Naoaki; ACTIS, Marcelo; PUNCHIHEWA, Chandanamali; CONNELLY, Michele; WU, Zhexiang
Patent: WO2013/6734 A1, 2013 ;
Location in patent: Paragraph 00567 ;
反应条件
phosphorus; hydrogen iodide; acetic acid 1 h; Reflux;
参考文献
Bridoux, Alexandre; Khan, Riaz A.; Chen, Celei; Cheve, Gwenael; Cui, Huadong; Dyskin, Evgeny; Yasri, Aziz; Mousa, Shaker A.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 6 p. 871 - 882
反应条件
1: pyridine / Erhitzen des erhaltenen Reaktionsgemisches mit 4-Methoxy-phenol 2: aqueous HCl; acetic acid 3: palladium/charcoal; acetic acid / Hydrogenation 4: NaNO2; H2SO4; acetic acid / Behandeln des Reaktionsgemisches mit NaI, Jod und Harnstoff in H2O unter Zusatz von CHCl3 5: aqueous HI; acetic acid View Scheme
参考文献
Journal of Organic Chemistry, , vol. 22, p. 1577,1580
反应条件
1: Py / benzene 2: H2 / Pd-C / ethanol 3: MeSO2Cl 4: (i) (catalytic hydrogenation), (ii) NaNO2, H2SO4, (iii) aq. NaI, I2, CHCl3, urea 5: aq. HCl / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 8, p. 469 - 474
反应条件
1: H2 / Pd-C / ethanol 2: MeSO2Cl 3: (i) (catalytic hydrogenation), (ii) NaNO2, H2SO4, (iii) aq. NaI, I2, CHCl3, urea 4: aq. HCl / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 8, p. 469 - 474
反应条件
1: aqueous HCl; acetic acid 2: palladium/charcoal; acetic acid / Hydrogenation 3: NaNO2; H2SO4; acetic acid / Behandeln des Reaktionsgemisches mit NaI, Jod und Harnstoff in H2O unter Zusatz von CHCl3 4: aqueous HI; acetic acid View Scheme
参考文献
Journal of Organic Chemistry, , vol. 22, p. 1577,1580
反应条件
hydrogenchloride in acetic acid
参考文献
Journal of Medicinal Chemistry, , vol. 8, p. 469 - 474
反应条件
1: (i) (nitration), (ii) /BRN= 1718733/, AcCl 2: MeSO2Cl 3: (i) (catalytic hydrogenation), (ii) NaNO2, H2SO4, (iii) aq. NaI, I2, CHCl3, urea 4: aq. HCl / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 8, p. 469 - 474
反应条件
1: MeSO2Cl 2: (i) (catalytic hydrogenation), (ii) NaNO2, H2SO4, (iii) aq. NaI, I2, CHCl3, urea 3: aq. HCl / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 8, p. 469 - 474
反应条件
1: (i) (catalytic hydrogenation), (ii) NaNO2, H2SO4, (iii) aq. NaI, I2, CHCl3, urea 2: aq. HCl / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 8, p. 469 - 474
