α,α-二苯基-4-哌啶甲醇合成路线 （共 34 条）
反应条件
1.1: potassium iodide; sodium hydrogencarbonate / toluene; water / 20 h / |Reflux 2.1: sodium hydroxide; water / methanol / 7 h / |Reflux 2.2: 15 h / 10 - 40 °C View Scheme
参考文献
CHEMELECTIVA S.r.l.; CASTALDI, Graziano; BARATELLA, Marco; GABOARDI, Mauro
Patent: US2013/237709 A1, 2013 ;
反应条件
potassium carbonate; potassium iodide in DMF (N,N-dimethyl-formamide); isobutyl methylketone T=120°C; 18 h;
参考文献
MATRIX LABORATORIES LIMITED
Patent: WO2009/136412 A2, 2009 ;
Location in patent: Page/Page column 8 ;
反应条件
potassium hydrogencarbonate; potassium iodide in water; toluene 72 h;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 98-99 ;
反应条件
sodium hydrogencarbonate; potassium iodide in water; toluene 20 h; Reflux;
参考文献
CHEMELECTIVA S.r.l.; CASTALDI, Graziano; BARATELLA, Marco; GABOARDI, Mauro
Patent: US2013/237709 A1, 2013 ;
Location in patent: Paragraph 0106 ;
反应条件
potassium hydrogencarbonate; potassium iodide in water; toluene 30 - 40 h; Heating / reflux; Product distribution / selectivity;
参考文献
WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; MERWADE, Aravind, Yekanathsa; KHAN, Anjum, Reyaz; SOLANKI, Pawan, Vrajlal
Patent: WO2007/7347 A1, 2007 ;
Location in patent: Page/Page column 4-5; 8; 11-12 ;
反应条件
1: α,α-dimethyl-(4-bromophenyl)acetic acid methyl ester; ethynylmethyl carbinol With potassium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in toluene 24 h; Reflux; 2: With sulfuric acid; mercury(II) oxide in methanol; water T=25 - 35°C; 2 h; 3: 4-(hydroxy-diphenyl-methyl)-piperidine
参考文献
Divi's Laboratories Limited
Patent: EP2532644 A1, 2012 ;
Location in patent: Page/Page column 6-7 ;
反应条件
in toluene 3 h; Heating / reflux;
参考文献
ZENTIVA, A.S.
Patent: WO2004/43922 A1, 2004 ;
Location in patent: Page 8 ;
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide; toluene Substitution; 7 h; Heating;
参考文献
Di Giacomo, Barbara; Coletta, Donato; Natalini, Benedetto; Ni, Ming-Hong; Pellicciari, Roberto
Farmaco, 1999 , vol. 54, # 9 p. 600 - 610
反应条件
in toluene 29 h; Heating / reflux;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 103-104 ;
反应条件
18-crown-6 ether; potassium carbonate; potassium iodide in acetonitrile
T=175°C; P=4875.49 Torr; 0.75 h; microwave irradiation;
参考文献
Holzer, Marcel; Ziegler, Sigrid; Albrecht, Beatrice; Kronenberger, Bernd; Kaul, Artur; Bartenschlager, Ralf; Kattner, Lars; Klein, Christian D.; Hartmann, Rolf W.
Molecules, 2008 , vol. 13, # 5 p. 1081 - 1110
