α,α-二苯基-4-哌啶甲醇合成路线 （共 34 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=70°C; P=2585.7 Torr;
参考文献
Walsh, David A.; Franzyshen, Stephen K.; Yanni, John M.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 105 - 118
反应条件
hydrogen; acetic acid; palladium on activated charcoal in ethanol T=25°C; Hydrogenolysis; P=3102.89 Torr; 2.5 h;
参考文献
Patel, Sunil; Waykole, Liladhar; Repic, Oljan; Chen, Kau-Ming
Synthetic Communications, 1996 , vol. 26, # 24 p. 4699 - 4710
反应条件
palladium monocarbide in ethanol
反应条件
potassium hydroxide in ethanol 24 h; Heating;
参考文献
Benaka Prasad; Vinaya; Ananda Kumar; Swarup, Sanjay; Rangappa
Medicinal Chemistry Research, 2010 , vol. 19, # 3 p. 220 - 235
反应条件
1: 1) Mg / 1) THF, reflux; 2) THF, room temperature, overnight 2: 99 percent / H2 / 5percent Pd/C / ethanol / 70 °C / 2585.7 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 1 p. 105 - 118
反应条件
1: 1) Mg / 1) THF, reflux; 2) THF, room temperature, overnight 2: 99 percent / H2 / 5percent Pd/C / ethanol / 70 °C / 2585.7 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 1 p. 105 - 118
反应条件
1: 99 percent / triethylamine / tetrahydrofuran; H2O / 2 h / 25 °C 2: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C 3: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr View Scheme
参考文献
Synthetic Communications, , vol. 26, # 24 p. 4699 - 4710
反应条件
1: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C 2: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr View Scheme
参考文献
Synthetic Communications, , vol. 26, # 24 p. 4699 - 4710
反应条件
acetic acid; platinum Hydrogenation;
反应条件
1: 70 percent / K2CO3 / CH2Cl2 / Ambient temperature 2: 75 percent / 50percent KOH / ethanol / 24 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 32, # 4 p. 475 - 476
