6-氯-2-甲基喹啉-3-羧酸乙酯合成路线 （共 5 条）
反应条件
1: With triethylamine; L-proline in dichloromethane T=20°C; Inert atmosphere; 2: With triphenylphosphine in dichloromethane T=20°C; Inert atmosphere;
参考文献
Yu, Zhi-Hua; Zheng, Hu-Fei; Yuan, Wei; Tang, Zi-Long; Zhang, Ai-Dong; Shi, De-Qing
Tetrahedron, 2013 , vol. 69, # 38 p. 8137 - 8141
反应条件
trichlorophosphate in DMF (N,N-dimethyl-formamide); 1,2-dichloro-ethane T=20°C; 7.16667 h; Heating / reflux;
参考文献
Takeuchi, Kumiko; Jirousek, Michael Robert; Paal, Michael; Ruhter, Gerd; Schotten, Theo
Patent: US2004/9976 A1, 2004 ;
Location in patent: Page/Page column 92 ;
反应条件
lithium trifluoromethane sulfonate in neat (no solvent) T=80°C; Friedlaender Quinoline Synthesis; 0.166667 h;
参考文献
Atar, Amol B.; Dindulkar, Someshwer D.; Jeong, Yeon Tae
Monatshefte fur Chemie, 2013 , vol. 144, # 5 p. 695 - 701
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate in 1,2-dichloro-ethane T=20°C; 0.166667 h; 2: ethyl 3-((4-chlorophenyl)amino)but-2-enoate in 1,2-dichloro-ethane T=20°C; Vilsmeier Formylation; 7 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: EP1266897 A2, 2002 ;
Location in patent: Page 110 ;
反应条件
trichlorophosphate 4 h; Heating;
参考文献
Adams, David R.; Colman, Trina de Saizarbitoria
Synthetic Communications, 1987 , vol. 17, # 14 p. 1647 - 1654
