(E)-4-羟基-N-去甲基他莫昔芬合成路线 （共 4 条）
反应条件
1: With magnesium sulfate in tetrahydrofuran T=20°C; 16 h; 2: With sodium tetrahydroborate in tetrahydrofuran; ethanol T=20°C; 1 h;
参考文献
Olema Pharmaceuticals, Inc.
Patent: US8063249 B1, 2011 ;
Location in patent: Page/Page column 58-59 ;
反应条件
in tetrahydrofuran T=60°C; 48 h;
参考文献
THE REGENTS OF THE UNIVERSITY OF COLORADO
Patent: WO2005/34856 A2, 2005 ;
Location in patent: Page/Page column 85 ;
反应条件
titanium tetrachloride; zinc in tetrahydrofuran T=20°C; McMurry reaction; Inert atmosphereReflux;
参考文献
Fauq, Abdul H.; Maharvi, Ghulam M.; Sinha, Dola
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 10 p. 3036 - 3038
反应条件
in water; isopropyl alcohol 48 h; Reflux; optical yield given as percent de;
参考文献
Ali, Shoukath M.; Ahmad, Ateeq; Shahabuddin, Syed; Ahmad, Moghis U.; Sheikh, Saifuddin; Ahmad, Imran
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2665 - 2667
