benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one T=-5 - 23°C; 12.25 h; Inert atmosphereLarge scale; TemperatureSolvent;

<b>Multi-step reaction with 5 steps<br /> </b>1: tetrahydrofuran / 3 h / 0 &deg;C<br />2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 0 &deg;C / |Inert atmosphere<br />3: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane; decane / 2 h / 0 - 20 &deg;C<br />4: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 &deg;C<br />5: hydrogen; palladium on carbon / methanol / 6 h / 0 &deg;C / 2660.18 Torr<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 &deg;C<br />1.2: 1 h / 20 &deg;C / |Inert atmosphere<br />2.1: tetrahydrofuran / 3 h / 0 &deg;C<br />3.1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 0 &deg;C / |Inert atmosphere<br />4.1: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane; decane / 2 h / 0 - 20 &deg;C<br />5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 &deg;C<br />6.1: hydrogen; palladium on carbon / methanol / 6 h / 0 &deg;C / 2660.18 Torr<br /> <br /> &nbsp;