2-氰基-4'-溴甲基联苯合成路线 （共 55 条）
反应条件
1: LiCl, (i-Pr)2NEt / tetrahydrofuran / 15 h / Heating 2: NaOMe / methanol / a) RT, 20 h, b) reflux, 2 h 3: POCl3 / toluene / 8 h / Heating 4: NH2NH2*H2O / ethanol / 2 h / Heating 5: 91 percent / various solvent(s) / 6 h / 160 - 165 °C 6: 86 percent / Me3SnN3 / benzene-d6 / 24 h / 115 °C View Scheme
参考文献
Nicolai; Cure; Goyard; Kirchner; Teulon; Versigny; Cazes; Caussade; Virone-Oddos; Cloarec
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2371 - 2386
反应条件
1: With potassium carbonate in 1-methyl-pyrrolidin-2-one
T=70 - 75°C;
2: With sodium tetrahydroborate in 1-methyl-pyrrolidin-2-one
T=30°C;
3: With water in 1-methyl-pyrrolidin-2-one; isopropyl alcohol
T=75 - 80°C; 1.5 h;
参考文献
ALEMBIC LIMITED; DEO, Keshav; DESAI, Sanjay; RATHOD, Dhiraj; PARIKH, Chirag; MOKAL, Ramesh
Patent: WO2010/29457 A2, 2010 ;
Location in patent: Page/Page column 11-12 ;
反应条件
sodium methylate in N-methyl-acetamide; hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US5663186 A1, 1997 ;
US 5663186 A
反应条件
in hexane; ethyl acetate
参考文献
Madasu, Suri Babu; Vekariya; Koteswaramma, Ch; Islam, Aminul; Sanasi, Paul Douglas; Korupolu, Raghu Babu
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 2025 - 2030
反应条件
1: 2-butyl-4-chloro-5-hydroxymethyl-1H-imidazole With sodium methylate in N,N-dimethyl-formamide
T=25°C; 0.5 h;
2: 2-[4-(bromomethyl)phenyl]benzonitrile in N,N-dimethyl-formamide
T=20°C; 24 h;
参考文献
Ambalavanan; Palani; Ponnuswamy; Thirumuruhan; Yathirajan; Prabhuswamy; Raju; Nagaraja; Mohana
Molecular Crystals and Liquid Crystals, 2003 , vol. 393, p. 75 - 82
