2-氰基-4'-溴甲基联苯合成路线 （共 55 条）
反应条件
1: 4-(dimethylamino)picolinaldehyde N,N-dibenzylhydrazone; bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I) / tetrahydrofuran / 24 h / 80 °C / |Inert atmosphere 2: palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; potassium phosphate / N,N-dimethyl-formamide / 80 °C / |Inert atmosphere 3: MMPP / methanol / 0 h / 20 °C 4: Na2S2O5; Sodium bromate / water; ethyl acetate / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 21 p. 9915 - 9920
反应条件
1: palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; potassium phosphate / N,N-dimethyl-formamide / 80 °C / |Inert atmosphere 2: MMPP / methanol / 0 h / 20 °C 3: Na2S2O5; Sodium bromate / water; ethyl acetate / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 21 p. 9915 - 9920
反应条件
1: MMPP / methanol / 0 h / 20 °C 2: Na2S2O5; Sodium bromate / water; ethyl acetate / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 21 p. 9915 - 9920
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / |Inert atmosphere 2: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 8 p. 2370 - 2378
反应条件
1: With potassium iodide; potassium hydroxide in acetonitrile T=20°C; 2 h; 2: With hydrogenchloride in water; acetonitrile pH=4 - 5; Product distribution / selectivity;
参考文献
KRKA, tovarna zdravil, d.d., Novo mesto
Patent: EP2194050 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=25 - 30°C; 12 h; 2: With hydrogenchloride in water; toluene T=20 - 30°C; 2 h;
参考文献
WO2012/56294 A1, ;
Page/Page column 14 ;
反应条件
sodium azide in N,N-dimethyl-formamide T=30 - 40°C; 0.5 h;
参考文献
Huang, Horng-Chih; Reitz, David B.; Chamberlain, Timothy S.; Olins, Gillian M.; Corpus. Valerie M.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2172 - 2181
反应条件
potassium carbonate in acetonitrile 4 h; Heating;
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
1: With potassium acetate in water; toluene T=90°C; 12 h; 2: With sodium hydroxide in water; toluene T=50 - 70°C; 5 h;
参考文献
Ciba-Geigy Corp
Patent: US5399578 A1, 1995 ;
US 5399578 A
反应条件
1: SR48001A With potassium carbonate; tetrabutylammomium bromide in water T=25 - 60°C; 2: 2-[4-(bromomethyl)phenyl]benzonitrile in water T=55 - 60°C; 3: With sodium azide; triethyl amine hydrochloride in toluene T=25 - 105°C; Product distribution / selectivity;
参考文献
CTX LIFE SCIENCES PVT. LTD.; KOLHE, Prakash, Yashwant; JOSHI, Rajesh, Dilip; SRIVASTAVA, Bimal, Kumar; PATEL, Nitin, Jerambhai; GAJJAR, Sanket, Sureshbhai
Patent: WO2010/116380 A2, 2010 ;
Location in patent: Page/Page column 10-11 ;
