2-氰基-4'-溴甲基联苯合成路线 （共 55 条）
反应条件
1: 72 percent / acetic anhydride; pyridine 2: 71 percent / copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C 3: 45 percent / N-bromosuccinimide; azobis(isobutyronitrile) / CCl4; cyclohexane / 18 h / 75 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 19 p. 7473 - 7476
反应条件
in water; chlorobenzene
参考文献
US2003/233009 A1, ;
Page column 5 ;
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 3: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 4: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 2: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 6: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 5: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere 2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 40 h / 80 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 9 p. 4407 - 4424
参考文献
US2002/115702 A1, ;
US 20020115702 A1
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere 2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 40 h / 80 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 9 p. 4407 - 4424
