4'-溴甲基-2-甲酸甲酯联苯合成路线 （共 24 条）
反应条件
1: 11 percent / Cu / 1 h / 210 °C 2: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 88 percent / 4.5 N aq. HCl / 12 h / Heating 3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 4: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 88 percent / 4.5 N aq. HCl / 12 h / Heating 4: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 5: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 88 percent / 4.5 N aq. HCl / 12 h / Heating 2: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 3: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 88 percent / 4.5 N aq. HCl / 12 h / Heating 6: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 7: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 88 percent / 4.5 N aq. HCl / 12 h / Heating 5: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 6: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1.1: potassium hydroxide / ethylene glycol / 48 h / 170 °C 2.1: potassium carbonate / acetone / 0.25 h 2.2: 24 h / Reflux 3.1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / Reflux View Scheme
参考文献
Archiv der Pharmazie, , vol. 344, # 9 p. 617 - 626
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / |Inert atmosphere 2: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 8 p. 2370 - 2378
反应条件
1: 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With sodium hydroxide in water; N,N-dimethyl-formamide T=0 - 5°C; 0.5 h; 2: methyl 4'-(bromomethyl)biphenyl-2-carboxylate in water; N,N-dimethyl-formamide 0.5 h;
参考文献
WO2012/28925 A2, ;
Page/Page column 20 ;
反应条件
1: 2-n-propyl-4-methyl-6-(1'-methylbenzimidazol-2'-yl)benzimidazole With potassium tert-butylate in dimethyl sulfoxide; isopropyl alcohol Inert atmosphere; 2: methyl 4'-(bromomethyl)biphenyl-2-carboxylate in dimethyl sulfoxide; isopropyl alcohol T=30 - 35°C; 6 h; Inert atmosphere;
参考文献
WO2011/102645 A2, ;
Page/Page column 13 ;
