(R)-1-苄基-3-氨基吡咯烷合成路线 （共 9 条）
反应条件
ammonia; hydrogen; nickel in methanol P=760 Torr;
参考文献
Iwanami; Takashima; Hirata; Hasegawa; Usuda
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1224 - 1230
反应条件
palladium on charcoal in tetrahydrofuran; water
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h; Heating;
参考文献
Jean, Ludovic; Baglin, Isabelle; Rouden, Jacques; Maddaluno, Jacques; Lasne, Marie-Claire
Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5645 - 5649
反应条件
1: 72 percent / aq. NH4OH / 12 h 2: 75 percent / PhI(OAc)2 / H2O; acetonitrile / 1 h / 20 °C 3: 80 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 33 p. 5645 - 5649
反应条件
1: 75 percent / PhI(OAc)2 / H2O; acetonitrile / 1 h / 20 °C 2: 80 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 33 p. 5645 - 5649
反应条件
1: 70 percent / TFA; NaNO2 / aq. NaOH / 2 h / 0 - 80 °C 2: 80 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 33 p. 5645 - 5649
反应条件
in dichloromethane T=20°C; 1.25 h; Heating / reflux;
参考文献
WO2009/76387 A1, ;
Page/Page column 23 ;
WO 2009/076387 A1
反应条件
in dichloromethane T=20°C;
参考文献
Huang; Luedtke; Freeman; Wu; Mach
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1815 - 1826
