(betaR)-4-溴-beta-环戊基-1H-吡唑-1-丙醛合成路线 （共 4 条）
反应条件
(2R)-2-(bis[3,5-bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]methyl)pyrrolidine; 4-nitro-benzoic acid in toluene T=0 - 20°C; 22.16 h;
参考文献
Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng
Patent: US2010/190981 A1, 2010 ;
Location in patent: Page/Page column 71-72 ;
US 20100190981 A1
反应条件
1: cyclopentane carboxaldehyde; (triphenylphosphoranylidene)-acetaldehyde in benzene T=80°C; Wittig olefination; 16 h; Inert atmosphere; 2: With (R)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol tert-butyldimethylsilyl ether; 4-nitro-benzoic acid in toluene T=0 - 20°C; Inert atmosphere; 3: 4-bromo(1H)-pyrazole in toluene T=0°C; Aza-Michael asymmetric addition; 22 h; optical yield given as percent ee;
参考文献
Lin, Qiyan; Meloni, David; Pan, Yongchun; Xia, Michael; Rodgers, James; Shepard, Stacey; Li, Mei; Galya, Laurine; Metcalf, Brian; Yue, Tai-N; Liu, Pingli; Zhou, Jiacheng
Organic Letters, 2009 , vol. 11, # 9 p. 1999 - 2002
反应条件
ammonium hydroxide; iodine in tetrahydrofuran; water T=20°C; 0.5 h;
参考文献
Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng
Patent: US2010/190981 A1, 2010 ;
Location in patent: Page/Page column 71-72 ;
US 20100190981 A1
反应条件
ammonia; iodine in tetrahydrofuran; water T=20°C; 0.5 h; optical yield given as percent ee;
参考文献
Lin, Qiyan; Meloni, David; Pan, Yongchun; Xia, Michael; Rodgers, James; Shepard, Stacey; Li, Mei; Galya, Laurine; Metcalf, Brian; Yue, Tai-N; Liu, Pingli; Zhou, Jiacheng
Organic Letters, 2009 , vol. 11, # 9 p. 1999 - 2002
