4-甲氧基苯基磷酸二乙酯合成路线 （共 39 条）
反应条件
1: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 26 h / 70 °C / Inert atmosphere 2: [2,2']bipyridinyl; copper (II) acetate monohydrate; potassium carbonate / dimethyl sulfoxide / 4 h / 110 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 353, # 18 p. 3340 - 3346
反应条件
sodium 1.) ethanol, 2.) DMF, RT, 3.) H2O; Yield given. Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 473 - 478
反应条件
1: 4-methoxy-benzaldehyde With lithium aluminium tetrahydride 2: With phosphorus tribromide 3: triethyl phosphite Arbusov reaction; Further stages.;
参考文献
European Journal of Organic Chemistry, , # 12 p. 1891 - 1904
反应条件
1: (p-methoxybenzyl)phosphonic acid ethyl ester With sodium methylate in N,N-dimethyl-formamide T=20°C; 0.333333 h; 2: 4-methoxy-benzaldehyde in N,N-dimethyl-formamide T=100°C; 7 h;
参考文献
Andrus, Merritt B.; Meredith, Erik L.; Simmons, Bryon L.; Sekhar, B. B. V. Soma; Hicken, Erik J.
Organic Letters, 2002 , vol. 4, # 20 p. 3549 - 3552
反应条件
1.1: NaOMe; tetrabutylammonium iodide / dimethylformamide / 1 h / 20 °C 1.2: 60.7 percent / dimethylformamide / 8 h / 40 °C 2.1: 90 percent / BBr3 / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Cai, Wenqing; Zhang, Liangwei; Song, Yanlin; Zhang, Baoxin; Cui, Xuemei; Hu, Guanming; Fang, Jianguo
Free Radical Research, 2011 , vol. 45, # 11-12 p. 1379 - 1387
反应条件
sodium ethanolate in ethanol; N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Chen, Guoliang; Shan, Wei; Wu, Yingliang; Ren, Lixiang; Dong, Jinhua; Ji, Zhizhong
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 12 p. 1587 - 1590
反应条件
1: (p-methoxybenzyl)phosphonic acid ethyl ester With 18-crown-6 ether; sodium methylate in N,N-dimethyl-formamide T=20°C; 0.0833333 h; 2: 4-dimethylamino-benzaldehyde in N,N-dimethyl-formamide T=20 - 120°C; Horner-Emmons-Wadsworth reaction; 6 h;
参考文献
Heynekamp, Justin J.; Weber, Waylon M.; Hunsaker, Lucy A.; Gonzales, Amanda M.; Orlando, Robert A.; Deck, Lorraine M.; Vander Jagt, David L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7182 - 7189
反应条件
1: (p-methoxybenzyl)phosphonic acid ethyl ester With 18-crown-6 ether; sodium methylate in N,N-dimethyl-formamide T=20°C; 0.0833333 h; 2: 3,4,5-trimethoxy-benzaldehyde in N,N-dimethyl-formamide T=20 - 120°C; Horner-Emmons-Wadsworth reaction; 6 h;
参考文献
Heynekamp, Justin J.; Weber, Waylon M.; Hunsaker, Lucy A.; Gonzales, Amanda M.; Orlando, Robert A.; Deck, Lorraine M.; Vander Jagt, David L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7182 - 7189
反应条件
sodium methylate in N,N-dimethyl-formamide T=20°C; Wittig reaction; 10 h;
参考文献
Free Radical Research, , vol. 45, # 11-12 p. 1379 - 1387
反应条件
1: NaOEt / dimethylformamide; ethanol / 3 h / 20 °C
2: BBr3 / CH2Cl2 / -10 - 0 °C
View Scheme
参考文献
Chen, Guoliang; Shan, Wei; Wu, Yingliang; Ren, Lixiang; Dong, Jinhua; Ji, Zhizhong
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 12 p. 1587 - 1590
