N-(2-吡嗪基羰基)-L-苯丙氨酸合成路线 （共 12 条）
反应条件
4-methyl-morpholine; 1-propanephosphonic acid cyclic anhydride in dichloromethane; acetonitrile T=-15 - 25°C; 1.5 h;
参考文献
SYNTHON BV; CASTULIK, Jakub; ZABADAL, Miroslav
Patent: WO2012/48745 A1, 2012 ;
Location in patent: Page/Page column 15 ;
反应条件
1: (S)-3-phenyl-2-(pyrazine-2-carboxamido) propanoic acid With benzotriazol-1-ol in dichloromethane T=-5°C; 0.333333 h; 2: (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxabor-ol-2-yl]butan-1-amine hydrochloride With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=-15 - 20°C; 3 h;
参考文献
Zhu, Yongqiang; Zhao, Xin; Zhu, Xinrong; Wu, Gang; Li, Yuejie; Ma, Yuheng; Yuan, Yunxia; Yang, Jie; Hu, Yang; Ai, Li; Gao, Qingzhi
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4192 - 4199
