4-[二(2-氯乙基)氨基]苯甲酸合成路线 （共 10 条）
反应条件
potassium permanganate in pyridine; water
T=20°C; 20 h;
参考文献
Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Champathong, Wattanachai; Lerdsirisuk, Pradit; Khotmor, Theeraphon; Techasakul, Supanna
Journal of Chemical Research, 2012 , vol. 36, # 6 p. 374 - 378
反应条件
1: With thionyl chloride in benzene
3 h; Reflux;
2: With hydrogenchloride; water
3 h; Reflux;
参考文献
Zheng, Qing-Zhong; Zhang, Fei; Cheng, Kui; Yang, Ying; Chen, Yu; Qian, Yong; Zhang, Hong-Juan; Li, Huan-Qiu; Zhou, Chang-Fang; An, Shu-Qing; Jiao, Qing-Cai; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 880 - 886
反应条件
1.1: trichlorophosphate / 1,2-dichloro-ethane / 0.17 h / 0 °C
1.2: 3 h / Reflux
2.1: potassium permanganate / pyridine; water / 20 h / 20 °C
View Scheme
参考文献
Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Champathong, Wattanachai; Lerdsirisuk, Pradit; Khotmor, Theeraphon; Techasakul, Supanna
Journal of Chemical Research, 2012 , vol. 36, # 6 p. 374 - 378
反应条件
bacterial enzyme carboxypeptidase (CPG2)
参考文献
Springer, Caroline J.; Antoniw, Pari; Bagshawe, Kenneth D.; Searle, Frances; Bisset, Graham M. F.; Jarman, Michael
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 677 - 681
反应条件
1: 77 percent / pyridine / 1.) 2 deg C, 20 min, 2.) 80 deg C, 80 min
2: 94 percent / trifluoroacetic acid / 0.5 h / Ambient temperature
3: bacterial enzyme carboxypeptidase (CPG2)
View Scheme
参考文献
Springer, Caroline J.; Antoniw, Pari; Bagshawe, Kenneth D.; Searle, Frances; Bisset, Graham M. F.; Jarman, Michael
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 677 - 681
反应条件
1: acetic acid
2: methanesulfonyl chloride; pyridine
3: trifluoroacetic acid / dichloromethane
View Scheme
参考文献
Frackowiak-Wojtasek, Bozena; Gasowska-Bajger, Beata; Mazurek, Magdalena; Raniszewska, Agnieszka; Logghe, Marieke; Smolarczyk, Ryszard; Cichon, Tomasz; Szala, Stanislaw; Wojtasek, Hubert
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 98 - 104
参考文献
Everett; Ross
Journal of the Chemical Society, 1949 , p. 1972,1974
反应条件
1: acetic acid / 130 °C
2: phosphorus oxychloride; chloroform
3: aqueous hydrochloric acid
View Scheme
参考文献
Everett; Ross
Journal of the Chemical Society, 1949 , p. 1972,1974
反应条件
1: trichlorophosphate
2: potassium permanganate
View Scheme
参考文献
Zhou, Sufeng; Fu, Yun; Fan, Xizhi; Zhang, Yanfang; Li, Changzheng
Medicinal Chemistry Research, 2013 , vol. 22, # 6 p. 2862 - 2869
反应条件
T=37°C; 3 h; bacterial carboxypeptidase enzyme (CPG2), pH 7.4; Rate constant;
参考文献
Dowell, Robert I.; Springer, Caroline J.; Davies, David H.; Hadley, Elizabeth M.; Burke, Philip J.; Boyle, F. Thomas; Melton, Roger G.; Connors, Thomas A.; Blakey, David C.; Mauger, Anthony B.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1100 - 1105
