6-乙酰氨基-4-羟基-2-甲基喹啉合成路线 （共 12 条）
反应条件
in diphenylether T=245 - 260°C; 0.25 h;
参考文献
WO2005/51392 A1, ;
Page/Page column 46 ;
参考文献
Journal of the Chemical Society, , p. 563,565
Gazzetta Chimica Italiana, , vol. 71, p. 53,57
Zhurnal Obshchei Khimii, , vol. 14, p. 1128,1132
Chem.Abstr., , p. 7194
反应条件
1: 93 percent / methanol / 17 h / Heating 2: 88 percent / various solvent(s) / 0.17 h / 280 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 24 p. 4667 - 4677
参考文献
Journal of the Chemical Society, , p. 563,565
反应条件
1: in toluene 6 h; Heating / reflux; 2: With sodium hydroxide in water pH=14;
参考文献
Zheng, Yi; Nassar, Nicolas; Skowronek, Karlheinz R.
Patent: US2007/155766 A1, 2007 ;
Location in patent: Page/Page column 28 ;
反应条件
1: POCl3 2: 130 - 140 °C View Scheme
参考文献
Jacini
Gazzetta Chimica Italiana, 1941 , vol. 71, p. 53,57
参考文献
Bangdiwala; Desai
Journal of the Indian Chemical Society, 1954 , vol. 31, p. 688
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Jacini
Gazzetta Chimica Italiana, 1939 , vol. 69, p. 111,115,116
Gazzetta Chimica Italiana, 1941 , vol. 71, p. 53,56
反应条件
1: toluene / Behandeln des Reaktionsprodukts mit wss. NaOH
2: 135 °C / Erwaermen des jeweiligen Reaktionsprodukts mit wss. HCl
3: acetic acid
View Scheme
参考文献
Pratt; Archer
Journal of the American Chemical Society, 1948 , vol. 70, p. 4065,4069
反应条件
trichlorophosphate
T=100°C; 0.5 h;
参考文献
Shinkai; Ito; Iida; Kitao; Yamada; Uchida
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4667 - 4677
反应条件
1: 52 percent / toluene / 8 h / Heating
2: AcONH4 / 4 h / 135 °C
3: aq. HCl / 5 h / 90 °C
4: pyridine / 3 h / 20 °C
View Scheme
参考文献
Shinkai; Ito; Iida; Kitao; Yamada; Uchida
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4667 - 4677
