4-溴-2,6-二叔丁基苯酚合成路线 （共 45 条）
反应条件
potassium phosphate; [(P{(NC5H10)(C6H11)2})2Pd(Cl)2] in toluene
T=80°C; Suzuki-Miyaura cross-coupling reaction; 0.5 h; Air;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Chemistry - A European Journal, 2010 , vol. 16, # 13 p. 4075 - 4081
反应条件
[(P{(NC5H10)(C6H11)2})2Pd(Cl)2] in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; 2 h; In air;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Chemistry - A European Journal, 2010 , vol. 16, # 36 p. 11072 - 11081
反应条件
1: (i) nBuLi, THF, hexane, (ii) /BRN= 1209232/
2: (i) nBuLi, Me2NCH2CH2NMe2, THF, hexane, (ii) /BRN= 506893/, (iii) aq. HCl
View Scheme
参考文献
Harrer,W. et al.
Tetrahedron, 1975 , vol. 31, p. 625 - 632
反应条件
1: (i) nBuLi, THF, hexane, (ii) /BRN= 1209232/
2: (i) nBuLi, Me2NCH2CH2NMe2, THF, hexane, (ii) /BRN= 906769/, (iii) aq. HCl
View Scheme
参考文献
Harrer,W. et al.
Tetrahedron, 1975 , vol. 31, p. 625 - 632
反应条件
1.1: 97 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C
2.1: t-BuLi; sulfur / tetrahydrofuran / -78 - -30 °C
2.2: tetrahydrofuran
3.1: 57 percent / Bu4NF / methanol / Heating
4.1: 100 percent / BH3*Me2S / tetrahydrofuran / Heating
View Scheme
参考文献
Bebbington, David; Monck, Nathaniel J. T.; Gaur, Suneel; Palmer, Alan M.; Benwell, Karen; Harvey, Victoria; Malcolm, Craig S.; Porter, Richard H. P.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2779 - 2782
