(顺式)-1,1'-(1,2-环丙烷二基)二苯合成路线 （共 66 条）
反应条件
1: 85 percent / sodium nitrite / acetic acid; H2O / 1. 0.5h, 0 degC; 2. r.t., 33h
2: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 60 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; toluene / 2 h / 70 °C / Inert atmosphere
2: tetrakis-dirhodium(II)-N-perfluorooctylsulfonyl-L-prolinate / tetrahydrofuran; toluene / 20 °C / Inert atmosphere
View Scheme
参考文献
Verdecchia, Mirella; Tubaro, Cristina; Biffis, Andrea
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1136 - 1139
反应条件
in cyclohexane
Isomerization; Cyclization; UV-irradiation; Title compound not separated from byproducts;
参考文献
Jimenez; Miranda; Tormos
Chemical Communications, 2000 , # 23 p. 2341 - 2342
反应条件
ClFeTPP; N-benzyl-N,N,N-triethylammonium chloride in toluene
T=40°C; Product distribution; Further Variations:SolventsTemperaturesReagents;
参考文献
Aggarwal, Varinder K.; De Vicente, Javier; Bonnert, Roger V.
Organic Letters, 2001 , vol. 3, # 17 p. 2785 - 2788
反应条件
1.1: diethylzinc; trifluoroacetic acid / dichloromethane / 0.67 h / 5 °C
1.2: 4 h / 5 - 20 °C
2.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 90 h / 20 °C / Inert atmosphere; UV-irradiation
View Scheme
参考文献
Cahard, Elise; Schoenebeck, Franziska; Garnier, Jean; Cutulic, Sylvain P. Y.; Zhou, Shengze; Murphy, John A.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3673 - 3676
反应条件
1.1: diethylzinc; trifluoroacetic acid / dichloromethane / 1.33 h / 5 °C
1.2: 38 h / 5 - 20 °C
2.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 11 h / 20 °C / Inert atmosphere; UV-irradiation
3.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 90 h / 20 °C / Inert atmosphere; UV-irradiation
View Scheme
参考文献
Cahard, Elise; Schoenebeck, Franziska; Garnier, Jean; Cutulic, Sylvain P. Y.; Zhou, Shengze; Murphy, John A.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3673 - 3676
反应条件
1.1: diethylzinc; trifluoroacetic acid / dichloromethane / 1.33 h / 5 °C
1.2: 5 h / 5 - 20 °C
2.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere; UV-irradiation
View Scheme
参考文献
Cahard, Elise; Schoenebeck, Franziska; Garnier, Jean; Cutulic, Sylvain P. Y.; Zhou, Shengze; Murphy, John A.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3673 - 3676
反应条件
1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 11 h / 20 °C / Inert atmosphere; UV-irradiation
2: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 90 h / 20 °C / Inert atmosphere; UV-irradiation
View Scheme
参考文献
Cahard, Elise; Schoenebeck, Franziska; Garnier, Jean; Cutulic, Sylvain P. Y.; Zhou, Shengze; Murphy, John A.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3673 - 3676
反应条件
p-Acetylbenzoesaeure-n-propylamid in benzene
96 h; Irradiationcis/trans-ratio depends on stabilisator;
参考文献
Horner, Leopold; Klaus, Joachim
Liebigs Annalen der Chemie, 1981 , # 5 p. 792 - 810
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium in toluene; pentane
12 h; Heating;
参考文献
Asuncion, Lisa A.; Baldwin, John E.
Croatica Chemica Acta, 1996 , vol. 69, # 4 p. 1421 - 1436
