(顺式)-1,1'-(1,2-环丙烷二基)二苯合成路线 （共 66 条）
反应条件
1: 64 percent / 12 h / -78 - 23 °C
2: 91 percent / hexachloroacetone, triphenylphosphine / tetrahydrofuran / 0.5 h / -78 °C
3: CsF
View Scheme
参考文献
Corey; Chen, Zhuoliang
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8731 - 8734
反应条件
1: lithium, naphthalene / tetrahydrofuran / 3 h / -30 °C
2: 64 percent / 12 h / -78 - 23 °C
3: 91 percent / hexachloroacetone, triphenylphosphine / tetrahydrofuran / 0.5 h / -78 °C
4: CsF
View Scheme
参考文献
Corey; Chen, Zhuoliang
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8731 - 8734
反应条件
1: 91 percent / hexachloroacetone, triphenylphosphine / tetrahydrofuran / 0.5 h / -78 °C
2: CsF
View Scheme
参考文献
Corey; Chen, Zhuoliang
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8731 - 8734
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 20 deg C, 1 h
2: n-BuLi / tetrahydrofuran / 0.7 h / -78 °C
View Scheme
参考文献
Krief, Alain; Hobe, Myriam; Dumont, Willy; Badaoui, Elie; Guittet, Eric; Evrard, Guy
Tetrahedron Letters, 1992 , vol. 33, # 23 p. 3381 - 3384
反应条件
1: 98 percent / pyridine / 2 h
2: sodium ethoxide / ethanol / 1.5 h
3: 11 percent / sodium / pentan-1-ol / Ambient temperature; overnight
4: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
5: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: 58 percent / thionyl chloride / 0.5 h / Heating
2: sodium ethoxide / ethanol / 1.5 h
3: 11 percent / sodium / pentan-1-ol / Ambient temperature; overnight
4: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
5: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: sodium ethoxide / ethanol / 1.5 h
2: 11 percent / sodium / pentan-1-ol / Ambient temperature; overnight
3: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
4: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
2,6-di-tert-butyl-pyridine; 9-CP in acetonitrile
Isomerization; Rearrangement; 9 h; Irradiation;
参考文献
Herbertz, Torsten; Lakkaraju, Prasad Sreeramachandra; Blume, Florian; Blume, Matthias; Roth, Heinz Dieter
European Journal of Organic Chemistry, 2000 , # 3 p. 467 - 472
反应条件
1: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
2: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: 11 percent / sodium / pentan-1-ol / Ambient temperature; overnight
2: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
3: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
